Wnt proteins are now recognized as one of the major families of developmentally important
signaling molecules, with mutations in Wnt genes displaying remarkable phenotypes in the …

▪ Abstract Wnt genes encode a large family of secreted, cysteine-rich proteins that play key
roles as intercellular signaling molecules in development. Genetic studies in Drosophila and …

Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease
characterized by the presence of adenomatous polyps in the colon and rectum, with …

Vertebrate gastrulation involves the specification and coordinated movement of large
populations of cells that give rise to the ectodermal, mesodermal and endodermal germ …

β-catenin is a pivotal player in the signaling pathway initiated by Wnt proteins, mediators of
several developmental processes. β-catenin activity is controlled by a large number of …

ABSTRACT β-catenin is a multifunctional protein found in three cell compartments: the
plasma membrane, the cytoplasm and the nucleus. The cell has developed elaborate ways …

Communication between cells is often mediated by secreted signaling molecules that bind
cell surface receptors and modulate the activity of specific intracellular effectors. The Wnt …

The activation of β-catenin to an oncogenic state can result from the inactivation of the tumor
suppressor adenomatous polyposis coli (APC), by direct mutation in the β-catenin gene, or …

In Drosophila, planar cell polarity (PCP) signaling is mediated by the receptor Frizzled (Fz)
and transduced by Dishevelled (Dsh). Wingless (Wg) signaling also requires Dsh and may …

Pathologic alterations in the microtubule-associated protein tau have been implicated in a
number of neurodegenerative disorders, including Alzheimer's disease (AD), progressive …