Post-translational modifications (PTMs) of histone proteins are a hallmark of epigenetic
regulation. They provide a mechanism to modulate chromatin structure and constitute the …

The post-translational modification of proteins expands the regulatory scope of the proteome
far beyond what is achievable through genome regulation. The field of protein citrullination …

Peptidylarginine deiminase II (PADI2) converts positively charged arginine residues to
neutrally charged citrulline, and this activity has been associated with the onset and …

Background Controlled modulation of nucleosomal DNA accessibility via post-translational
modifications (PTM) is a critical component to many cellular functions. Charge-altering PTMs …

The post-translational modification of arginine residues represents a key mechanism for the
epigenetic control of gene expression. Aberrant levels of histone arginine modifications …

The generation of post-translational modifications (PTMs) in human proteins is a
physiological process leading to structural and immunologic variety in proteins, with …

Citrullination, the deimination of peptidylarginine residues into peptidylcitrulline, has been
implicated in the etiology of several diseases. In multiple sclerosis, citrullination is thought to …

Abstract Peptide arginine deiminase 2 (PAD2) catalyzes the conversion of arginine residues
on target proteins to citrulline residues in the presence of calcium ions. This particular …

Protein arginine deimination leading to the non-coded amino acid citrulline remains a key
question in the field of post-translational modifications ever since its discovery by Rogers …

Glucocorticoid hormone plays a major role in metabolism and disease. The hormone-bound
glucocorticoid receptor (GR) binds to a specific set of enhancers in different cell types …