The Golgi apparatus is an essential cellular organelle that mediates homeostatic functions,
including vesicle trafficking and the post-translational modification of macromolecules. Its …

Muscular dystrophies encompass a wide and heterogeneous subset of hereditary
myopathies that manifest by the structural or functional abnormalities in the skeletal muscle …

Emerging evidence indicates that cellular senescence could be a critical inducing factor for
aging-associated neurodegenerative disorders. However, the involvement of cellular …

Impairment in glucocerebrosidase (GCase) is strongly associated with the development of
Parkinson's disease (PD), yet the regulators responsible for its impairment remain elusive. In …

Parkinson's disease (PD) is the second most common neurodegenerative disorder that
results in motor dysfunction and, eventually, cognitive impairment. α-Synuclein protein is …

The vast majority of gene mutations and/or gene knockouts result in either no observable
changes, or significant deficits in molecular, cellular, or organismal function. However, in a …

This article critically evaluates the multifunctional role of the Golgi apparatus within
neurological paradigms. We succinctly highlight its influence on neuronal plasticity …

Neurological disorders are prevalent in patients with chronic kidney disease (CKD).
Vascular factors and uremic toxins are involved with cognitive impairment in CKD. In …

Objective GluA1-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors (AMPARs) inserted into postsynaptic membranes are key to the process of long …

Cells comprise several intracellular membrane compartments that allow them to function
properly. One of these functions is cargo movement, typically proteins and membranes …