E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at
adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …

The homeobox (HOX) genes encoding an evolutionarily highly conserved family of
homeodomain-containing transcriptional factors are essential for embryogenesis and …

Recently, novel mechanisms underlying the pro-tumorigenic effects of cancer-associated
fibroblasts (CAFs) have been identified in several cancers, including breast cancer. CAFs …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Chronic infections of the fallopian tubes with Chlamydia trachomatis (Ctr) cause scarring
and can lead to infertility. Here we use human fallopian tube organoids and genital Ctr …

Although the use of oral administration of pharmacological all-trans retinoic acid (ATRA)
concentration in acute promyelocytic leukaemia (APL) patients was approved for over 20 …

The roles of HOX transcription factors as oncogenes and tumor suppressor genes, and the
NF-KB pathway in chronic inflammation, both leading to cancer are well-established. HOX …

HOX genes occupy a significant role in embryogenesis, hematopoiesis, and oncogenesis.
HOXA5, a member of the A cluster of HOX genes, is essential for establishing the skeleton …

The HOX and PBX gene families encode transcription factors that have key roles in
establishing the identity of cells and tissues in early development. Over the last 20 years it …

HOX family transcription factors belong to a highly conserved subgroup of the homeobox
superfamily that determines cellular fates in embryonic morphogenesis and the …