The unfulfilled promise of inhaled therapy in ventilator-associated infections: where do we go from here?

LB Palmer, GC Smaldone - … of aerosol medicine and pulmonary drug …, 2022 - liebertpub.com
Respiratory infection is common in intubated/tracheotomized patients and systemic antibiotic
therapy is often unrewarding. In 1967, the difficulty in treating Gram-negative respiratory …

Inhaled drug delivery: a randomized study in intubated patients with healthy lungs

J Dugernier, D Le Pennec, G Maerckx… - Annals of intensive …, 2023 - Springer
Background The administration technique for inhaled drug delivery during invasive
ventilation remains debated. This study aimed to compare in vivo and in vitro the deposition …

Impact of gas humidification and nebulizer position under invasive ventilation: preclinical comparative study of regional aerosol deposition

Y Montigaud, Q Georges, L Leclerc, A Clotagatide… - Scientific Reports, 2023 - nature.com
Successful aerosol therapy in mechanically ventilated patients depends on multiple factors.
Among these, position of nebulizer in ventilator circuit and humidification of inhaled gases …

Real-Time In Vitro Assessment of Aerosol Delivery During Mechanical Ventilation

M McPeck, JA Lee, AD Cuccia… - Journal of Aerosol …, 2022 - liebertpub.com
Background: A new real-time method for assessing factors determining aerosol delivery is
described. Methods: A breath-enhanced jet nebulizer operated in a ventilator/heated …

In Vitro Comparison of Inspiration-Synchronized and Continuous Vibrating Mesh Nebulizer During Adult Invasive Mechanical Ventilation

J Li, CA Sheridan, O Alanazi, JB Fink - Journal of Aerosol Medicine …, 2024 - liebertpub.com
Background: Aerosol delivery may be enhanced by utilizing an inspiration-synchronized
nebulization mode, where nebulization occurs only during inspiration. This study aimed to …

Multidrug Aerosol Delivery During Mechanical Ventilation

AD Cuccia, M McPeck, JA Lee… - Journal of Aerosol …, 2023 - liebertpub.com
Background: In the critically ill, pulmonary vasodilators are often provided off label to
intubated patients using continuous nebulization. If additional aerosol therapies such as …

Optimizing Aerosolized Drug Delivery in Clinical Trials in Patients Undergoing Mechanical Ventilation

TG O'Riordan - Journal of Aerosol Medicine and Pulmonary Drug …, 2024 - liebertpub.com
Determining the dose–response of a novel inhaled medication is complicated by the fact that
the dose deposited in the lung cannot be extrapolated from the dose placed in the delivery …

Ventilator breathing circuit with a nebulizer between the ventilator and humidifier

G Smaldone - US Patent App. 18/269,371, 2024 - Google Patents
A ventilator circuit apparatus is provided for the administration of nebulized drugs to a
patient on a mechanical ventilator. The apparatus has a breathing circuit with an inspiratory …

[引用][C] Real-time analysis of dry-side nebulization with heated wire humidification during mechanical ventilation

JA Lee, M McPeck, AD Cuccia, GC Smaldone - Respiratory Care, 2022 - Respiratory Care

[引用][C] Influence of aerosol mask design on fugitive aerosol concentrations during nebulization

CE Chiang, HH Li, DD Rowley, TP Fang… - Respiratory Care, 2023 - Respiratory Care