Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma
Objectives Oesophageal squamous cell carcinoma (OSCC) is an aggressive malignancy
and the major histological subtype of oesophageal cancer. Although recent large-scale …
and the major histological subtype of oesophageal cancer. Although recent large-scale …
[HTML][HTML] Synthesis of selective PAK4 inhibitors for lung metastasis of lung cancer and melanoma cells
P Song, F Zhao, D Li, J Qu, M Yao, Y Su… - … Pharmaceutica Sinica B, 2022 - Elsevier
The p21 activated kinase 4 (PAK4) is serine/threonine protein kinase that is critical for
cancer progression. Guided by X-ray crystallography and structure-based optimization, we …
cancer progression. Guided by X-ray crystallography and structure-based optimization, we …
Design, synthesis and biological evaluation of novel benzimidazole-derived p21-activited kinase 4 (PAK4) inhibitors bearing a 4-(4-methylpiperazin-1-yl) phenyl …
S Hao, L Hou, J Wang, J Yan, Y Niu, Z Cai, F Li… - European Journal of …, 2024 - Elsevier
Abstract A series of novel 6-(4-(4-methylpiperazin-1-yl) phenyl)-1H-benzo [d] imidazole-
based p21-activited kinase 4 (PAK4) inhibitors were designed and synthesized based on …
based p21-activited kinase 4 (PAK4) inhibitors were designed and synthesized based on …
Strategy and validation of a structure-based method for the discovery of selective inhibitors of PAK isoforms and the evaluation of their anti-cancer activity
PL Song, G Wang, Y Su, HX Wang, J Wang, F Li… - Bioorganic …, 2019 - Elsevier
Abstract p21 activated kinase 4 (PAK4), which belongs to the serine/threonine (Ser/Thr)
protein kinase family, is a representative member of the PAK family and plays a significant …
protein kinase family, is a representative member of the PAK family and plays a significant …