Cisplatin nephrotoxicity: new insights and therapeutic implications

C Tang, MJ Livingston, R Safirstein… - Nature Reviews …, 2023 - nature.com
Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Cisplatin in cancer treatment

AMP Romani - Biochemical pharmacology, 2022 - Elsevier
Cisplatin is a widely used chemotherapy agent in the treatment of various forms of
carcinomas and sarcomas. Its effectiveness in delaying negative outcome in cancer patients …

Cisplatin nephrotoxicity: a review of the literature

S Manohar, N Leung - Journal of nephrology, 2018 - Springer
Cisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It
remains an important and effective therapy in many forms of cancer today. Cisplatin …

Recent advances in models, mechanisms, biomarkers, and interventions in cisplatin-induced acute kidney injury

SJ Holditch, CN Brown, AM Lombardi… - International journal of …, 2019 - mdpi.com
Cisplatin is a widely used chemotherapeutic agent used to treat solid tumours, such as
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …

Possibility of magnesium supplementation for supportive treatment in patients with COVID-19

CF Tang, H Ding, RQ Jiao, XX Wu, LD Kong - European journal of …, 2020 - Elsevier
Magnesium as an enzymatic activator is essential for various physiological functions such as
cell cycle, metabolic regulation, muscle contraction, and vasomotor tone. A growing body of …

Cisplatin in liver cancer therapy

S Hamaya, K Oura, A Morishita, T Masaki - International Journal of …, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) is the most common primary liver tumor and is often
diagnosed at an unresectable advanced stage. Systemic chemotherapy as well as …

Pro-inflammatory signalling PRRopels cisplatin-induced toxicity

IK Domingo, A Latif, AP Bhavsar - International journal of molecular …, 2022 - mdpi.com
Cisplatin is a platinum-based chemotherapeutic that has long since been effective against a
variety of solid-cancers, substantially improving the five-year survival rates for cancer …

Primordial germ cells: current knowledge and perspectives

A Nikolic, V Volarevic, L Armstrong… - Stem cells …, 2016 - Wiley Online Library
Infertility is a condition that occurs very frequently and understanding what defines normal
fertility is crucial to helping patients. Causes of infertility are numerous and the treatment …

Derivation and external validation of a simple risk score for predicting severe acute kidney injury after intravenous cisplatin: cohort study

S Gupta, IG Glezerman, JS Hirsch, KL Chen, N Devaraj… - bmj, 2024 - bmj.com
Objective To develop and externally validate a prediction model for severe cisplatin
associated acute kidney injury (CP-AKI). Design Multicenter cohort study. Setting Six …

Magnesium replacement to protect cardiovascular and kidney damage? Lack of prospective clinical trials

JR Muñoz-Castañeda… - International Journal of …, 2018 - mdpi.com
Patients with advanced chronic kidney disease exhibit an increase in cardiovascular
mortality. Recent works have shown that low levels of magnesium are associated with …