The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity

Y Xiong, BB Mi, Z Lin, YQ Hu, L Yu, KK Zha… - Military Medical …, 2022 - Springer
Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy”

A Trzyna, A Banaś-Ząbczyk - Biomolecules, 2021 - mdpi.com
Adipose-derived stem cells (ASCs) secrete many cytokines, proteins, growth factors, and
extracellular vesicles with beneficial outcomes that can be used in regenerative medicine. It …

[HTML][HTML] Recent development in multizonal scaffolds for osteochondral regeneration

L Yu, S Cavelier, B Hannon, M Wei - Bioactive Materials, 2023 - Elsevier
Osteochondral (OC) repair is an extremely challenging topic due to the complex biphasic
structure and poor intrinsic regenerative capability of natural osteochondral tissue. In …

Mesenchymal stem cell-derived exosomes exert ameliorative effects in type 2 diabetes by improving hepatic glucose and lipid metabolism via enhancing autophagy

Q He, L Wang, R Zhao, F Yan, S Sha, C Cui… - Stem cell research & …, 2020 - Springer
Background Mesenchymal stem cell (MSC)-based therapy is currently considered to be an
effective treatment strategy for diabetes and hepatic disorders, such as liver cirrhosis and …

Physical cue‐based strategies on peripheral nerve regeneration

Z Wei, F Jin, T Li, L Qian, W Zheng… - Advanced Functional …, 2023 - Wiley Online Library
Peripheral nerve injury (PNI) remains an intractable challenge in regenerative medicine.
Recently, physical cue‐based strategies (eg, electrical neurostimulation, acoustic radiation …

State of the art: the immunomodulatory role of MSCs for osteoarthritis

DG Kwon, MK Kim, YS Jeon, YC Nam, JS Park… - International journal of …, 2022 - mdpi.com
Osteoarthritis (OA) has generally been introduced as a degenerative disease; however, it
has recently been understood as a low-grade chronic inflammatory process that could …

Pulsed electromagnetic field stimulation in osteogenesis and chondrogenesis: signaling pathways and therapeutic implications

K Varani, F Vincenzi, S Pasquini, I Blo, S Salati… - International Journal of …, 2021 - mdpi.com
Mesenchymal stem cells (MSCs) are the main cell players in tissue repair and thanks to their
self-renewal and multi-lineage differentiation capabilities, they gained significant attention …

Heparinized Acellular Hydrogels for Magnetically Induced Wound Healing Applications

F Pires, JC Silva, FC Ferreira… - ACS Applied Materials & …, 2024 - ACS Publications
The control of angiogenesis has the potential to be used for regulation of several
pathological and physiological processes, which can be instrumental on the development of …

Small extracellular vesicles from menstrual blood-derived mesenchymal stem cells (MenSCs) as a novel therapeutic impetus in regenerative medicine

L Chen, J Qu, Q Mei, X Chen, Y Fang, L Chen… - Stem Cell Research & …, 2021 - Springer
Menstrual blood-derived mesenchymal stem cells (MenSCs) have great potential in
regenerative medicine. MenSC has received increasing attention owing to its impressive …

[HTML][HTML] Brief exposure to directionally-specific pulsed electromagnetic fields stimulates extracellular vesicle release and is antagonized by streptomycin: A potential …

CJK Wong, YK Tai, JLY Yap, CHH Fong, LSW Loo… - Biomaterials, 2022 - Elsevier
Pulsing electromagnetic fields (PEMFs) have been shown to promote in vitro and in vivo
myogeneses via mitohormetic survival adaptations of which secretome activation is a key …