The mitochondrial permeability transition pore: channel formation by F-ATP synthase, integration in signal transduction, and role in pathophysiology
P Bernardi, A Rasola, M Forte… - Physiological …, 2015 - journals.physiology.org
The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …
Metabolic control of cell death
Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …
been considered two independent entities. On one side stood the catabolic and anabolic …
Dimers of mitochondrial ATP synthase form the permeability transition pore
V Giorgio, S Von Stockum, M Antoniel… - Proceedings of the …, 2013 - National Acad Sciences
Here we define the molecular nature of the mitochondrial permeability transition pore (PTP),
a key effector of cell death. The PTP is regulated by matrix cyclophilin D (CyPD), which also …
a key effector of cell death. The PTP is regulated by matrix cyclophilin D (CyPD), which also …
ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy
Mitochondrial permeability transition pore (MPTP) formation contributes to ischemia-
reperfusion injury in the heart and several degenerative diseases, including muscular …
reperfusion injury in the heart and several degenerative diseases, including muscular …
Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition
The term mitochondrial permeability transition (MPT) is commonly used to indicate an abrupt
increase in the permeability of the inner mitochondrial membrane to low molecular weight …
increase in the permeability of the inner mitochondrial membrane to low molecular weight …
Linking oxidative stress and DNA damage to changes in the expression of extracellular matrix components
SG Martins, R Zilhão, S Thorsteinsdóttir… - Frontiers in …, 2021 - frontiersin.org
Cells are subjected to endogenous [eg, reactive oxygen species (ROS), replication stress]
and exogenous insults (eg, UV light, ionizing radiation, and certain chemicals), which can …
and exogenous insults (eg, UV light, ionizing radiation, and certain chemicals), which can …
Mitochondrial permeability transition: a molecular lesion with multiple drug targets
T Briston, DL Selwood, G Szabadkai… - Trends in pharmacological …, 2019 - cell.com
Mitochondrial permeability transition, as the consequence of opening of a mitochondrial
permeability transition pore (mPTP), is a cellular catastrophe. Initiating bioenergetic collapse …
permeability transition pore (mPTP), is a cellular catastrophe. Initiating bioenergetic collapse …
Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration
P Grumati, L Coletto, P Sabatelli, M Cescon… - Nature medicine, 2010 - nature.com
Autophagy is crucial in the turnover of cell components, and clearance of damaged
organelles by the autophagic-lysosomal pathway is essential for tissue homeostasis …
organelles by the autophagic-lysosomal pathway is essential for tissue homeostasis …
Physiopathology of the permeability transition pore: Molecular mechanisms in human pathology
Mitochondrial permeability transition (MPT) is the sudden loss in the permeability of the
inner mitochondrial membrane (IMM) to low-molecular-weight solutes. Due to osmotic …
inner mitochondrial membrane (IMM) to low-molecular-weight solutes. Due to osmotic …
Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore
JW Elrod, JD Molkentin - Circulation Journal, 2013 - jstage.jst.go.jp
1112 ELROD JW et al. red-sensitive mechanism (now known to be the mitochondrial
calcium uniporter (MCU), the genetic identity of which was recently discovered14–16) and …
calcium uniporter (MCU), the genetic identity of which was recently discovered14–16) and …