Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets
Mesenchymal stem cells, also known as mesenchymal stromal cells (MSCs), exist in many
tissues and are known to actively migrate to sites of tissue injury, where they participate in …
tissues and are known to actively migrate to sites of tissue injury, where they participate in …
Detection, clinical relevance and specific biological properties of disseminating tumour cells
Most cancer deaths are caused by haematogenous metastatic spread and subsequent
growth of tumour cells at distant organs. Disseminating tumour cells present in the …
growth of tumour cells at distant organs. Disseminating tumour cells present in the …
Cancer-associated fibroblasts and tumor growth–bystanders turning into key players
A Östman, M Augsten - Current opinion in genetics & development, 2009 - Elsevier
Novel mechanisms, and molecular mediators, of the pro-tumorigenic effects of cancer-
associated fibroblasts (CAFs) have been identified. These include CXCL12/SDF-1-mediated …
associated fibroblasts (CAFs) have been identified. These include CXCL12/SDF-1-mediated …
[HTML][HTML] Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression
M Shimoda, KT Mellody, A Orimo - Seminars in cell & developmental …, 2010 - Elsevier
Tumours are highly complex tissues composed of carcinoma cells and surrounding stroma,
which is constructed by various different types of mesenchymal cells and an extracellular …
which is constructed by various different types of mesenchymal cells and an extracellular …
Cancer cells metabolically" fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors
UE Martinez-Outschoorn, Z Lin, C Trimmer… - Cell cycle, 2011 - Taylor & Francis
Previously, we proposed that cancer cells behave as metabolic parasites, as they use
targeted oxidative stress as a “weapon” to extract recycled nutrients from adjacent stromal …
targeted oxidative stress as a “weapon” to extract recycled nutrients from adjacent stromal …
Clinical implications and utility of field cancerization
GD Dakubo, JP Jakupciak, MA Birch-Machin… - Cancer cell …, 2007 - Springer
Cancer begins with multiple cumulative epigenetic and genetic alterations that sequencially
transform a cell, or a group of cells in a particular organ. The early genetic events might lead …
transform a cell, or a group of cells in a particular organ. The early genetic events might lead …
Breast-Cancer Stromal Cells with TP53 Mutations and Nodal Metastases
Background The importance of cross-talk between a cancer and its microenvironment has
been increasingly recognized. We hypothesized that mutational inactivation of the tumor …
been increasingly recognized. We hypothesized that mutational inactivation of the tumor …
Prognostic significance of stromal platelet-derived growth factor β-receptor expression in human breast cancer
This study systematically analyzes platelet-derived growth factor (PDGF) receptor
expression in six types of common tumors as well as examines associations between PDGF …
expression in six types of common tumors as well as examines associations between PDGF …
Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation
S Bornstein, R White, S Malkoski, M Oka… - The Journal of …, 2009 - Am Soc Clin Investig
Smad4 is a central mediator of TGF-β signaling, and its expression is downregulated or lost
at the malignant stage in several cancer types. In this study, we found that Smad4 was …
at the malignant stage in several cancer types. In this study, we found that Smad4 was …
Tumor stroma as targets for cancer therapy
J Zhang, J Liu - Pharmacology & therapeutics, 2013 - Elsevier
Cancer is not only composed malignant epithelial component but also stromal components
such as fibroblasts, endothelial cells, and inflammatory cells, by which an appropriate tumor …
such as fibroblasts, endothelial cells, and inflammatory cells, by which an appropriate tumor …