Abstract The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of
signal transduction and biological processes such as cell proliferation, apoptosis …

Simple Summary Hemangiosarcoma is a mesenchymal neoplasm that originates in the
endothelial cells of blood vessels. According to the location of origin, they can be classified …

Introduction Baicalein, a bioactive component of Scutellaria baicalensis Georgi, has been
shown to promote apoptosis in non-small cell lung cancer cells. However, previous studies …

Tuberous sclerosis complex (TSC) is a rare autosomal dominant neurocutaneous syndrome.
It is manifested mainly in cutaneous lesions, epilepsy and the emergence of hamartomas in …

Prostate cancer (PCa) in dogs is a highly malignant disease akin to its human counterpart. In
contrast to the situation in humans, multi-gene approaches facilitating risk stratification of …

Mammary adenocarcinoma, the most common cancer in female dogs, often exhibits the
lymph node and lung metastases and has a higher mortality rate. However, mammary …

Down syndrome (DS) is the most common genetic cause of intellectual impairment,
characterised by an extra copy of chromosome 21. After the age of 40, DS individuals are …

Simple Summary Prostate cancer (PC) is one of the main types of cancer that affects the
male population worldwide. In recent decades, there has been a significant evolution in the …

Canine tumors are valuable comparative models for human counterparts, especially to
explore novel biomarkers and to understand pathways and processes involved in …

Dogs are one of few species that naturally develop prostate cancer (PCa), which clinically
resembles aggressive, advanced PCa in humans. Moreover, PCa-tumor samples from dogs …