Abstract Objectives Meglumine antimoniate (MA; Glucantime®), the 80‐year‐old first‐line
systemic treatment for all forms of American tegumentary leishmaniasis (ATL) caused by …

Abstract Leishmaniasis is a Neglected Tropical Diseases caused by protozoan parasites of
the genus Leishmania. It is a major health problem in many tropical and subtropical regions …

Leishmaniasis is considered a serious public health problem and the current available
therapy has several disadvantages, which makes the search for new therapeutic targets and …

Objective To investigate the in vitro activity, synergism, cytotoxicity and cellular
immunological response, as well as the molecular affinity between amphotericin B (AmB) …

Leishmaniasis is a neglected parasitic disease for which the conventional treatment can be
considered inefficient and extremely aggressive, generating several and severe side effects …

Background: Considering the high toxicity and limited therapies available for treating
visceral leishmaniasis (VL), the drug repositioning approach represents a faster way to …

The inadequacy of available treatments for leishmaniasis has presented up to 40%
therapeutic failure. This fact suggests an urgency in the discovery of new drugs or alternative …

Translational studies involving the reuse and association of drugs are approaches that can
result in higher success rates in the discovery and development of drugs for serious public …

Although among the six most common parasitic diseases, leishmaniasis is considered a
neglected disease, being recognised as a serious public health burden worldwide. This fact …

Worldwide parasite infection, especially Leishmania, is the most severe high morbidity and
mortality issue. It is one of the leading protozoans parasitic agents responsible for causing …