DPP-4 inhibitors and type 2 diabetes mellitus in Parkinson's disease: a mutual relationship
M Alrouji, HM Al-Kuraishy, AK Al-Buhadily… - Pharmacological …, 2023 - Springer
Parkinson's disease (PD) usually occurs due to the degeneration of dopaminergic neurons
in the substantia nigra (SN). Management of PD is restricted to symptomatic improvement …
in the substantia nigra (SN). Management of PD is restricted to symptomatic improvement …
Nutraceuticals Unveiled a Multifaceted Neuroprotective Mechanisms for Parkinson's Disease: Elixir for the Brain
Introduction Nutraceuticals are food-derived products offering supplementary health
benefits. These nutraceuticals have been found effective in the treatment of the Parkinson's …
benefits. These nutraceuticals have been found effective in the treatment of the Parkinson's …
[HTML][HTML] Nuclear Receptors in Health and Diseases
P Xu - International Journal of Molecular Sciences, 2023 - mdpi.com
Nuclear receptors (NRs) are a vital superfamily of transcription factors that play crucial roles
in physiology and pharmacology [1]. The human genome comprises 48 NRs, 24 of which …
in physiology and pharmacology [1]. The human genome comprises 48 NRs, 24 of which …
Alterations in Blood Methylome as Potential Epigenetic Biomarker in Sporadic Parkinson's Disease
P Gonzalez‐Latapi, B Bustos, S Dong… - Annals of …, 2024 - Wiley Online Library
Objective To characterize DNA methylation (DNAm) differences between sporadic
Parkinson's disease (PD) and healthy control (HC) individuals enrolled in the Parkinson's …
Parkinson's disease (PD) and healthy control (HC) individuals enrolled in the Parkinson's …
2-Butoxytetrahydrofuran, Isolated from Holothuria scabra, Attenuates Aggregative and Oxidative Properties of α-Synuclein and Alleviates Its Toxicity in a Transgenic …
S Promtang, T Sanguanphun, P Chalorak… - ACS Chemical …, 2024 - ACS Publications
Aggregative α-synuclein and incurring oxidative stress are pivotal cascading events, leading
to dopaminergic (DAergic) neuronal loss and contributing to clinical manifestations of …
to dopaminergic (DAergic) neuronal loss and contributing to clinical manifestations of …
[HTML][HTML] RNA sequencing of olfactory bulb in Parkinson's disease reveals gene alterations associated with olfactory dysfunction
C Tremblay, S Aslam, JE Walker, I Lorenzini… - Neurobiology of …, 2024 - Elsevier
The olfactory bulb is involved early in the pathophysiology of Parkinson's disease (PD),
which is consistent with the early onset of olfactory dysfunction. Identifying the molecular …
which is consistent with the early onset of olfactory dysfunction. Identifying the molecular …
Retinoid X Receptor as a Novel Drug Target to Treat Neurological Disorders Associated with α-Synucleinopathies.
The pathology of Parkinson Disease (PD) is multifaceted, with chronic neuroinflammation
associated with glial cell activation standing out as a hallmark of PD pathophysiology. While …
associated with glial cell activation standing out as a hallmark of PD pathophysiology. While …