HIV-infected children and adolescents are exposed to HIV and antiretroviral therapy for
many decades starting early in life and during the most critical time for skeletal growth and …

Background Faltered linear growth and pubertal delay, which are both common in children
with HIV in sub-Saharan Africa, might affect adolescent bone accrual and future fragility …

Background No once-daily single-tablet regimen is available for HIV-infected children under
12 years. The single-tablet, fixed-dose combination of elvitegravir, cobicistat, emtricitabine …

Pediatric physiologically‐based pharmacokinetic (P‐PBPK) models have been used to
predict age related changes in the pharmacokinetics (PKs) of renally cleared drugs mainly in …

Introduction The scale-up of antiretroviral therapy (ART) across sub-Saharan Africa (SSA)
has reduced mortality so that increasing numbers of children with HIV (CWH) are surviving …

The higher risk of osteoporosis and fracture associated with HIV infection and certain
antiretrovirals has been well established and the need for risk stratification among older …

Objective: To investigate the impact of tenofovir disoproxil fumarate on bone mineral density
and bone mineral content in children and adolescents infected with the human …

Objectives: HIV infection impairs bone density in children living with HIV (CLWH). We aimed
to determine the prevalence of self-reported fracture (past or current), associated risk factors …

Background: Pregnant and breastfeeding women in Option B+ in Malawi received
antiretroviral drugs (ARVs) containing efavirenz (EFV) and tenofovir disoproxil fumarate …

Abstract Fixed-Dose antiretroviral Combinations (FDCs) are the most used drug regimes in
adult patients with human-immunodeficiency virus 1 infection, since they increase …