Traumatic brain injury (TBI), caused by physical insults to the head, involves complex
pathophysiological processes that damage the brain at multiple length scales. Unlike …

Transient pore formation on the membrane of red blood cells (RBCs) under high mechanical
tensions is of great importance in many biomedical applications, such as RBC damage …

In recent years, extracellular vesicles have become promising carriers as next-generation
drug delivery platforms. Effective loading of exogenous cargos without compromising the …

Cell membrane rupture occurs universally and is long thought to be the terminal event of cell
death; however, there is an inadequate understanding of the microscopic mechanisms of …

Epidemiology studies of traumatic brain injury (TBI) show individuals with a prior history of
TBI experience an increased risk of future TBI with a significantly more detrimental outcome …

Abstract Chronic Traumatic Encephalopathy (CTE) affects a significant portion of athletes in
contact sports but is difficult to quantify using clinical examinations and modeling …

Nanoscale deformation mechanisms of cellular structures could render drastically different
results depending on the molecular dynamics (MD) simulator chosen. Due to different …

In this study, a rate-dependent biphasic model will be introduced to account for
phenomenological behavior of brain tissue. For this purpose, a poro-hyper viscoelastic …

In this dissertation, we present our work on utilizing molecular dynamics (MD) simulations at
various scales to understand the pore formation process on the red blood cell (RBC) …

Abstract Model of nanoscale deformation mechanisms of cellular structures could render
different results depending on the molecular dynamics (MD) simulator chosen. Also, the …