Abstract Information storage and retrieval is essential for all life. In biology, information is
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …

Organismal aging is inherently connected to the aging of its constituent cells and systems.
Reducing the biological age of the organism may be assisted by reducing the age of its cells …

Aging is a complex multifactorial process associated with epigenome dysregulation,
increased cellular senescence, and decreased rejuvenation capacity. Short-term cyclic …

Aging and age‐associated disease are a major medical and societal burden in need of
effective treatments. Cellular reprogramming is a biological process capable of modulating …

The impressive achievements made in the last century in extending the lifespan have led to
a significant growth rate of elderly individuals in populations across the world and an …

Cellular plasticity in adult multicellular organisms is a protective mechanism that allows
certain tissues to regenerate in response to injury. Considering that aging involves exposure …

Brain aging leads to a decline in cognitive function and a concomitant increase in the
susceptibility to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases …

Globally, age-related diseases represent a significant public health concern among the
elderly population. In aging, healthy organs and tissues undergo structural and functional …

Partial reprogramming (pulsed expression of reprogramming transcription factors) improves
the function of several tissues in old mice. However, it remains largely unknown how partial …

Epigenetic aging clocks have been widely used to validate rejuvenation effects during
cellular reprogramming. However, these predictions are unverifiable because the true …