Mammalian dentition consists of teeth that develop as discrete organs. From anterior to
posterior, the dentition is divided into regions of incisor, canine, premolar and molar tooth …

Odontoblasts produce most of the extracellular matrix (ECM) components found in dentin
and implicated in dentin mineralization. Major differences in the pulp ECM explain why pulp …

Neural crest cells are multipotential stem cells that contribute extensively to vertebrate
development and give rise to various cell and tissue types. Determination of the fate of …

Most connective tissues in the head develop from neural crest cells (NCCs), an embryonic
cell population present only in vertebrates. We show that NCC-derived pericytes and smooth …

There has been rapid progress recently in the identification of signalling pathways
regulating tooth development. It has become apparent that signalling networks involved in …

Craniofacial malformations are involved in three fourths of all congenital birth defects in
humans, affecting the development of head, face, or neck. Tremendous progress in the study …

All ectodermal organs, eg hair, teeth, and many exocrine glands, originate from two adjacent
tissue layers: the epithelium and the mesenchyme. Similar sequential and reciprocal …

Discusses the development and general structure of the periodontium through emphasis on
the origin and lineage of cells. Use of technological innovations for documentation of cell …

Mammalian tooth development is largely dependent on sequential and reciprocal epithelial-
mesenchymal interactions. These processes involve a series of inductive and permissive …

Cleft palate and skull malformations represent some of the most frequent congenital birth
defects in the human population. Previous studies have shown that TGFβ signaling …