Mechanisms of mucosal healing: treating inflammatory bowel disease without immunosuppression?

EJ Villablanca, K Selin, CRH Hedin - Nature Reviews Gastroenterology …, 2022 - nature.com
Almost all currently available treatments for inflammatory bowel disease (IBD) act by
inhibiting inflammation, often blocking specific inflammatory molecules. However, given the …

The role of innate and adaptive immune cells in the pathogenesis and development of the inflammatory response in ulcerative colitis

A Kałużna, P Olczyk, K Komosińska-Vassev - Journal of clinical medicine, 2022 - mdpi.com
Ulcerative colitis (UC) is a chronic inflammatory disease with an underlying excessive
immune response directed against resident microbiota and/or dietary antigens. Both innate …

Hypoxia: A key feature of COVID-19 launching activation of HIF-1 and cytokine storm

M Jahani, S Dokaneheifard, K Mansouri - Journal of inflammation, 2020 - Springer
COVID-19, disease caused by the new coronavirus, SARS-CoV-2, appeared in the end of
2019 and was rapidly spread in most countries. This respiratory virus has different symptoms …

[HTML][HTML] Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats

B Li, P Du, Y Du, D Zhao, Y Cai, Q Yang, Z Guo - Life sciences, 2021 - Elsevier
Ulcerative colitis (UC) is a chronic inflammatory bowel disease related to intestinal
dysbiosis. Luteolin has been reported to reduce inflammation. However, it remains unclear …

Pathophysiology of inflammatory bowel disease: innate immune system

A Saez, B Herrero-Fernandez, R Gomez-Bris… - International journal of …, 2023 - mdpi.com
Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis
(UC), is a heterogeneous state of chronic intestinal inflammation with no exact known cause …

Astragaloside Ⅳ alleviates ulcerative colitis by regulating the balance of Th17/Treg cells

Y Zhong, W Liu, Y Xiong, Y Li, Q Wan, W Zhou, H Zhao… - Phytomedicine, 2022 - Elsevier
Background Restoring immune homeostasis by targeting the Th17/Treg response is a
potentially valuable therapeutic strategy for ulcerative colitis (UC). Astragaloside IV (AS-Ⅳ) …

Nuciferine alleviates intestinal inflammation by inhibiting MAPK/NF-κB and NLRP3/Caspase 1 pathways in vivo and in vitro

U Kulhari, S Kundu, MN Mugale, BD Sahu - International …, 2023 - Elsevier
Nuciferine (NCF) is an aporphine alkaloid and a principal bioactive constituent in the lotus
plant. Herewith, we investigated the potential anti-inflammatory effect and underlying …

Atractylodin attenuates dextran sulfate sodium-induced colitis by alleviating gut microbiota dysbiosis and inhibiting inflammatory response through the MAPK pathway

L Qu, X Lin, C Liu, C Ke, Z Zhou, K Xu… - Frontiers in …, 2021 - frontiersin.org
In this study, we investigated the therapeutic effects and mechanism of atractylodin (ATL) on
dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. We found that atractylodin …

Mechanistic insights into the role of probiotics in modulating immune cells in ulcerative colitis

N Guo, L Lv - Immunity, Inflammation and Disease, 2023 - Wiley Online Library
Background Ulcerative colitis (UC) is a persistent inflammatory disorder that affects the
gastrointestinal tract, mainly the colon, which is defined by inflammatory responses and the …

Qingre Xingyu recipe exerts inhibiting effects on ulcerative colitis development by inhibiting TNFα/NLRP3/Caspase-1/IL-1β pathway and macrophage M1 polarization

L Ning, N Ye, B Ye, Z Miao, T Cao, W Lu, D Xu… - Cell Death …, 2023 - nature.com
As a chronic inflammatory bowel disease, ulcerative colitis (UC) imposes a significant
burden on public healthcare worldwide due to its increasing morbidity. Chinese medicines …