Single photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging for radiotherapy planning in patients with lung cancer: a meta …

SJ Lee, HJ Park - Scientific Reports, 2020 - nature.com
Functional imaging modalities enable practitioners to identify functional lung regions. This
analysis evaluated the feasibility of nuclear medicine imaging to avoid doses to the …

Emerging strategies of engineering and tracking dendritic cells for cancer immunotherapy

Y Gao, Z Wang, Y Cui, M Xu, L Weng - ACS Applied Bio Materials, 2022 - ACS Publications
Dendritic cells (DCs), a kind of specialized immune cells, play key roles in antitumor immune
response and promotion of innate and adaptive immune responses. Recently, many …

Measuring indirect radiation-induced perfusion change in fed vasculature using dynamic contrast CT

AE Wuschner, MJ Flakus, EM Wallat… - Journal of personalized …, 2022 - mdpi.com
Recent functional lung imaging studies have presented evidence of an “indirect effect” on
perfusion damage, where regions that are unirradiated or lowly irradiated but that are …

CT-derived vessel segmentation for analysis of post-radiation therapy changes in vasculature and perfusion

AE Wuschner, MJ Flakus, EM Wallat… - Frontiers in …, 2022 - frontiersin.org
Vessel segmentation in the lung is an ongoing challenge. While many methods have been
able to successfully identify vessels in normal, healthy, lungs, these methods struggle in the …

A transfer learning framework for deep learning-based CT-to-perfusion mapping on lung cancer patients

G Ren, B Li, S Lam, H Xiao, YH Huang… - Frontiers in …, 2022 - frontiersin.org
Purpose Deep learning model has shown the feasibility of providing spatial lung perfusion
information based on CT images. However, the performance of this method on lung cancer …

Synthetic pulmonary perfusion images from 4DCT for functional avoidance using deep learning

EM Porter, NK Myziuk, TJ Quinn… - Physics in Medicine …, 2021 - iopscience.iop.org
Purpose. To develop and evaluate the performance of a deep learning model to generate
synthetic pulmonary perfusion images from clinical 4DCT images for patients undergoing …

Comparison of dual-energy CT with positron emission tomography for lung perfusion imaging in patients with non-small cell lung cancer

M Gaudreault, J Korte, N Bucknell… - Physics in Medicine …, 2023 - iopscience.iop.org
Objective. Functional lung avoidance (FLA) radiotherapy treatment aims to spare lung
regions identified as functional from imaging. Perfusion contributes to lung function and can …

Reliability of quantitative 18F-FDG PET/CT imaging biomarkers for classifying early response to chemoradiotherapy in patients with locally advanced non–small cell …

KP Horn, HMT Thomas, HJ Vesselle… - Clinical nuclear …, 2021 - journals.lww.com
Results Interobserver variability of PET contours was low for both OSEM and BSREM-TOF
reconstructions; intraobserver variability between reconstructions was slightly higher. ΔSUV …

Validation of CT-based ventilation and perfusion biomarkers with histopathology confirms radiation-induced pulmonary changes in a porcine model

MJ Flakus, AE Wuschner, EM Wallat, M Graham… - Scientific reports, 2023 - nature.com
Imaging biomarkers can assess disease progression or prognoses and are valuable tools to
help guide interventions. Particularly in lung imaging, biomarkers present an opportunity to …

The increasing potential of nuclear medicine imaging for the evaluation and reduction of normal tissue toxicity from radiation treatments

V Mohan, NM Bruin, JB van de Kamer, JJ Sonke… - European Journal of …, 2021 - Springer
Radiation therapy is an effective treatment modality for a variety of cancers. Despite several
advances in delivery techniques, its main drawback remains the deposition of dose in …