Interpretation of presynaptic phenotypes of synaptic plasticity in terms of a two-step priming process

E Neher - Journal of General Physiology, 2023 - rupress.org
Studies on synaptic proteins involved in neurotransmitter release often aim at distinguishing
between their roles in vesicle priming (the docking of synaptic vesicles to the plasma …

A sequential two-step priming scheme reproduces diversity in synaptic strength and short-term plasticity

KH Lin, H Taschenberger… - Proceedings of the …, 2022 - National Acad Sciences
Glutamatergic synapses display variable strength and diverse short-term plasticity (STP),
even for a given type of connection. Using nonnegative tensor factorization and …

Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse

JJ Chen, WA Kaufmann, C Chen, I Arai, O Kim… - Neuron, 2024 - cell.com
The coupling between Ca 2+ channels and release sensors is a key factor defining the
signaling properties of a synapse. However, the coupling nanotopography at many …

Three small vesicular pools in sequence govern synaptic response dynamics during action potential trains

V Tran, T Miki, A Marty - Proceedings of the National …, 2022 - National Acad Sciences
During prolonged trains of presynaptic action potentials (APs), synaptic release reaches a
stable level that reflects the speed of replenishment of the readily releasable pool (RRP) …

Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming

C Keine, M Al-Yaari, T Radulovic, CI Thomas… - Elife, 2022 - elifesciences.org
Synapses contain a limited number of synaptic vesicles (SVs) that are released in response
to action potentials (APs). Therefore, sustaining synaptic transmission over a wide range of …

A maximum of two readily releasable vesicles per docking site at a cerebellar single active zone synapse

M Silva, V Tran, A Marty - Elife, 2024 - elifesciences.org
Recent research suggests that in central mammalian synapses, active zones contain several
docking sites acting in parallel. Before release, one or several synaptic vesicles (SVs) are …

The last steps before synaptic vesicle release: calcium-dependent docking and functional implication of docking site organisation

MSM Weil - 2023 - theses.hal.science
The release of synaptic vesicles (SV) is regulated by the calcium concentration in the
presynaptic terminal. Before release a vesicle must bind to a specific structure within the …

[PDF][PDF] 脳神経シナプス生理学研究: 過去から未来へ

三木崇史 - 秋田医学, 2024 - air.repo.nii.ac.jp
生体で起こる分泌は, 代謝の調整, ストレス反応, 成長と発達, 消化吸収, そして脳神経の情報伝達
など, 生体の様々な機能で重要な役割を果たします. 脳神経系での分泌, 特に神経伝達物質放出は …