KH Lin, H Taschenberger… - Proceedings of the …, 2022 - National Acad Sciences
Glutamatergic synapses display variable strength and diverse short-term plasticity (STP), even for a given type of connection. Using nonnegative tensor factorization and …
JJ Chen, WA Kaufmann, C Chen, I Arai, O Kim… - Neuron, 2024 - cell.com
The coupling between Ca 2+ channels and release sensors is a key factor defining the signaling properties of a synapse. However, the coupling nanotopography at many …
V Tran, T Miki, A Marty - Proceedings of the National …, 2022 - National Acad Sciences
During prolonged trains of presynaptic action potentials (APs), synaptic release reaches a stable level that reflects the speed of replenishment of the readily releasable pool (RRP) …
C Keine, M Al-Yaari, T Radulovic, CI Thomas… - Elife, 2022 - elifesciences.org
Synapses contain a limited number of synaptic vesicles (SVs) that are released in response to action potentials (APs). Therefore, sustaining synaptic transmission over a wide range of …
M Silva, V Tran, A Marty - Elife, 2024 - elifesciences.org
Recent research suggests that in central mammalian synapses, active zones contain several docking sites acting in parallel. Before release, one or several synaptic vesicles (SVs) are …
The release of synaptic vesicles (SV) is regulated by the calcium concentration in the presynaptic terminal. Before release a vesicle must bind to a specific structure within the …