KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders

X Teng, A Aouacheria, L Lionnard… - CNS neuroscience & …, 2019 - Wiley Online Library
The underlying molecular basis for neurodevelopmental or neuropsychiatric disorders is not
known. In contrast, mechanistic understanding of other brain disorders including …

Methylation of elongation factor 1A: where, who, and why?

JJ Hamey, MR Wilkins - Trends in biochemical sciences, 2018 - cell.com
Eukaryotic elongation factor 1A (eEF1A) is an essential and highly conserved protein
involved in diverse cellular processes, including translation, cytoskeleton organisation …

Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injury

D Romaus-Sanjurjo, JM Saikia, HJ Kim, KM Tsai… - Cell Death …, 2022 - nature.com
Although protein synthesis is hypothesized to have a pivotal role in axonal repair after
central nervous system (CNS) injury, the role of core components of the protein synthesis …

Autism- and epilepsy-associated EEF1A2 mutations lead to translational dysfunction and altered actin bundling

MS Mohamed, E Klann - Proceedings of the National …, 2023 - National Acad Sciences
Protein synthesis is a fundamental cellular process in neurons that is essential for synaptic
plasticity and memory consolidation. Here, we describe our investigations of a neuron-and …

[HTML][HTML] The eEF1 family of mammalian translation elongation factors

BS Negrutskii, VF Shalak, OV Novosylna, LV Porubleva… - BBA advances, 2023 - Elsevier
The eEF1 family of mammalian translation elongation factors is comprised of the two
variants of eEF1A (eEF1A1 and eEF1A2), and the eEF1B complex. The latter consists of …

Elongation factor 1A1 regulates metabolic substrate preference in mammalian cells

RB Wilson, AM Kozlov, HH Tehrani… - Journal of Biological …, 2024 - ASBMB
Eukaryotic elongation factor 1A1 (EEF1A1) is canonically involved in protein synthesis, but
also has non-canonical functions in diverse cellular processes. Previously, we identified …

Comparison of the ability of mammalian eEF1A1 and its oncogenic variant eEF1A2 to interact with actin and calmodulin

O Novosylna, A Doyle, D Vlasenko, M Murphy… - Biological …, 2017 - degruyter.com
The question as to why a protein exerts oncogenic properties is answered mainly by well-
established ideas that these proteins interfere with cellular signaling pathways. However …

MLIF alleviates SH-SY5Y neuroblastoma injury induced by oxygen-glucose deprivation by targeting eukaryotic translation elongation factor 1A2

Q Zhu, Y Zhang, Y Liu, H Cheng, J Wang, Y Zhang… - PloS one, 2016 - journals.plos.org
Monocyte locomotion inhibitory factor (MLIF), a heat-stable pentapeptide, has been shown
to exert potent anti-inflammatory effects in ischemic brain injury. In this study, we …

eEF1α2 is required for actin cytoskeleton homeostasis in the aging muscle

H Katow, HD Ryoo - Disease Models & Mechanisms, 2024 - journals.biologists.com
The translation elongation factor eEF1α (eukaryotic elongation factor 1α) mediates mRNA
translation by delivering aminoacyl-tRNAs to ribosomes. eEF1α also has other reported …

Identification of a Specific Translational Machinery via TCTP–EF1A2 Interaction Regulating NF1-associated Tumor Growth by Affinity Purification and Data …

D Kobayashi, T Tokuda, K Sato, H Okanishi… - Molecular & Cellular …, 2019 - ASBMB
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease that predisposes
individuals to developing benign neurofibromas and malignant peripheral nerve sheath …