Oxidative stress is a phenomenon caused by an imbalance between production and
accumulation of oxygen reactive species (ROS) in cells and tissues and the ability of a …

Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

Glutathione is the principal intracellular antioxidant buffer against oxidative stress and
mainly exists in the forms of reduced glutathione (GSH) and oxidized glutathione (GSSG) …

Reactive oxygen species (ROS) play a major role in carcinogenesis: pro-oxidant agents like
tobacco smoke, asbestos or N-nitrosamines, are known as mutagenic and carcinogenic, and …

Background: Glutathione (GSH), the primary antioxidant in cells, could fight against oxidative
stress. Tumor cells display a higher GSH level than normal cells for coping with the …

Apoptosis is a highly organized form of cell death that is important for tissue homeostasis,
organ development and senescence. To date, the extrinsic (death receptor mediated) and …

Glutathione (L-γ-glutamyl-L-cysteinyl-glycine; GSH) in cancer cells is particularly relevant in
the regulation of carcinogenic mechanisms; sensitivity against cytotoxic drugs, ionizing …

Glutathione (GSH) has a crucial role in cellular signaling and antioxidant defenses either by
reacting directly with reactive oxygen or nitrogen species or by acting as an essential …

Significance: Glutathione (GSH) depletion is a central signaling event that regulates the
activation of cell death pathways. GSH depletion is often taken as a marker of oxidative …

Evidence of obesity-induced oxidative stress in adults has emerged in the past several
years, and similar evidence has been demonstrated in children more recently. The reactive …