Amyloids are protein aggregates bearing a highly ordered cross β structural motif, which
may be functional but are mostly pathogenic. Their formation, deposition in tissues and …

Prion-like seeded misfolding of host proteins is the leading hypothesised cause of
neurodegenerative diseases. The exploitation of the mechanism in the protein misfolding …

If theories postulating that pathological proteins associated with neurodegenerative
disorders behave similarly to prions were initially viewed with reluctance, it is now well …

The hypothesis that pathogenic protein aggregates associated with neurodegenerative
diseases spread from cell-to-cell in the brain in a manner akin to infectious prions has …

Huntington's disease is caused by a CAG repeat expansion in the Huntingtin gene (HTT),
coding for polyglutamine in the Huntingtin protein, with longer CAG repeats causing earlier …

Huntington's Disease (HD) is a fatal, neurodegenerative disease caused by aggregation of
the huntingtin protein (htt) with an expanded polyglutamine (polyQ) domain into amyloid …

Huntington's disease (HD) is a rare neurodegenerative disorder caused by an expansion of
CAG trinucleotide repeat located in the exon 1 of Huntingtin (HTT) gene in human …

Huntington's disease (HD) is a genetically inherited neurodegenerative disorder caused by
expansion of a polyglutamine (polyQ) repeat in the exon-1 of huntingtin protein (HTT). The …

The CAG/CAA expansion encoding polyQ huntingtin (mutant huntingtin [mHTT]) causes
Huntington's disease (HD), which is characterized by atrophy and loss of striatal medium …

Huntington's disease (HD) is a neurodegenerative disorder caused by the expansion of the
polyglutamine (polyQ) segment in the exon 1 of the huntingtin (HttEx1) protein. This polyQ …