Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and
proliferation. As such, most human cancers differ from normal counterpart tissues by a …

Although low risk localised prostate cancer has an excellent prognosis owing to effective
treatments, such as surgery, radiation, cryosurgery and hormone therapy, metastatic …

Cancer cells require a massive supply of nutrients, including sugars and amino acids—the
upregulation of transporters for each nutrient contributes to meet the demand. Distinct from …

Cells and organisms must coordinate their metabolic activity with changes in their
environment to ensure their growth only when conditions are favourable. In order to maintain …

Amino acid transporters (AATs) are membrane-bound transport proteins that mediate
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …

Alanine, serine, cysteine-preferring transporter 2 (ASCT2; SLC1A5) mediates uptake of
glutamine, a conditionally essential amino acid in rapidly proliferating tumour cells. Uptake …

Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are
highly dependent on nutrients in order to duplicate their cell mass during each cell division …

Glutamine is conditionally essential in cancer cells, being utilized as a carbon and nitrogen
source for macromolecule production, as well as for anaplerotic reactions fuelling the …

Cell metabolism and growth are matched to nutrient availability via the amino-acid-regulated
mechanistic target of rapamycin complex 1 (mTORC1). Transporters have emerged as …

The L-type amino acid transporter (LAT) family are Na+-independent transporters, which
deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 …