F Ahmad, MK Cherukuri, PL Choyke - British journal of cancer, 2021 - nature.com
Although low risk localised prostate cancer has an excellent prognosis owing to effective treatments, such as surgery, radiation, cryosurgery and hormone therapy, metastatic …
Y Kanai - Pharmacology & therapeutics, 2022 - Elsevier
Cancer cells require a massive supply of nutrients, including sugars and amino acids—the upregulation of transporters for each nutrient contributes to meet the demand. Distinct from …
Y Rabanal-Ruiz, EG Otten… - Essays in biochemistry, 2017 - portlandpress.com
Cells and organisms must coordinate their metabolic activity with changes in their environment to ensure their growth only when conditions are favourable. In order to maintain …
P Kandasamy, G Gyimesi, Y Kanai… - Trends in biochemical …, 2018 - cell.com
Amino acid transporters (AATs) are membrane-bound transport proteins that mediate transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …
P Häfliger, RP Charles - International journal of molecular sciences, 2019 - mdpi.com
Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are highly dependent on nutrients in order to duplicate their cell mass during each cell division …
Glutamine is conditionally essential in cancer cells, being utilized as a carbon and nitrogen source for macromolecule production, as well as for anaplerotic reactions fuelling the …
Cell metabolism and growth are matched to nutrient availability via the amino-acid-regulated mechanistic target of rapamycin complex 1 (mTORC1). Transporters have emerged as …
Q Wang, J Holst - American journal of cancer research, 2015 - ncbi.nlm.nih.gov
The L-type amino acid transporter (LAT) family are Na+-independent transporters, which deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 …