Almost 30 years ago it was first appreciated that anti-apoptotic B-cell lymphoma-2 (BCL-2)
prevents the induction of apoptosis not only in malignant cells, but also in normal cellular …

Programmed cell death is essential for the development and maintenance of cellular
homeostasis of the immune system. The Bcl-2 family of proteins comprises both pro …

Lung-resident memory CD8 T cells (TRM) induced by influenza A virus (IAV) that are pivotal
for providing subtype-transcending protection against IAV infection (heterosubtypic …

A fraction of mature T cells can be activated by peripheral self-antigens, potentially eliciting
host autoimmunity. We investigated homeostatic control of self-activated T cells within …

The inhibitory receptor programmed cell death 1 (PD-1) plays a major role in functional
exhaustion of T cells during chronic infections and cancer, and recent clinical data suggest …

Background The processes that drive fibrotic diseases are complex and include an influx of
peripheral blood monocytes that can differentiate into fibroblast-like cells called fibrocytes …

Antigen injection into animals causes antigen-specific T cells to become activated and,
rapidly thereafter, die. This antigen-induced death is inhibited by inflammation. To find out …

During illness and stress, the immune system can suffer a considerable loss of T cells
(lymphopenia). The remaining T cells undergo vigorous compensatory expansion, known as …

Pathological processes involved in the initiation of rheumatoid synovitis remain unclear. We
undertook the present study to identify immune and stromal processes that are present soon …

Background and aims: Treatment with infliximab induces remission in about 70% of patients
with steroid refractory Crohn's disease. Because Crohn's disease is considered to be …