Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell
response that most likely contributes to virus control in COVID-19 patients but may also …

We completed clinical trials of rhIL-15 by bolus, subcutaneous, and continuous intravenous
infusions (CIV). IL-15 administered by CIV at 2 mcg/kg/day yielded a 38-fold increase in 10 …

IL-15, a pleiotropic cytokine, stimulates generation of NK, NK-T, γδ, ILC1, and memory CD8
T cells. IL-15 disorders play pathogenetic roles in organ-specific autoimmune diseases …

Increasing evidence demonstrates that interleukin-10 (IL-10), known as an
immunosuppressive cytokine, induces antitumor effects depending on CD8+ T cells …

Adaptive immune responses rely on the proliferation of T lymphocytes able to recognize and
eliminate pathogens. The magnitude and duration of the expansion of activated T cell clones …

It is unclear how CD4 T-cell memory formation is regulated following pathogen challenge,
and when critical mechanisms act to determine effector T-cell fate. Here, we report that …

This narrative review provides an overview of the evolving significance of lymphopenia in
sepsis, emphasizing its critical function in this complex and heterogeneous disease. We …

Highlights•Evolution of host cell death pathways was driven by virus-encoded cell death
suppressors.•Caspase 8 regulates extrinsic apoptosis as well as programmed …