All implanted biomaterials are targets of the host's immune system. While the host
inflammatory response was once considered a detrimental force to be blunted or avoided, in …

A coordinated interaction between osteogenesis and osteoimmune microenvironment is
essential for successful bone healing. In particular, macrophages play a central regulatory …

Background Innate immune cells such as macrophages are abundantly present within
malignant ascites, where they share the microenvironment with ovarian cancer stem cells …

Diabetic foot ulcers (DFUs) are a devastating complication for diabetic patients that have
debilitating effects and can ultimately lead to limb amputation. Healthy wounds progress …

Chronic wounds are the result of disruptions in the body's usual process of healing. They are
not only a source of significant pain and discomfort but also, more importantly, an unguarded …

The binding of platelet-derived growth factor D (PDGF-DD) to the NKp44 receptor activates a
distinct transcriptional program in primary IL-2 expanded human natural killer (NK) cells. We …

Between 5 and 10 percent of fractures do not heal, a condition known as nonunion. In
clinical practice, stable fracture fixation associated with autologous iliac crest bone graft …

Activation of natural killer (NK) cell function is regulated by cytokines, such as IL-2, and
secreted factors upregulated in the tumor microenvironment, such as platelet-derived growth …

Recently, efforts have been made toward the harmonization of transcriptomic data structures
and workflows using the concept of data tidiness, to facilitate modularisation. We present …

Background The aim of this study is to analyze the effects of peripheral blood mononuclear
cells (PBMNCs) therapy in diabetic patients with critical limb ischemia (CLI), with particular …