Control of protein levels by nucleic-acid-based technologies has proven to be a useful
research tool but lacks the advantages of small molecules with respect to cell permeability …

Understanding the factors that shape viral evolution is critical for developing effective
antiviral strategies, accurately predicting viral evolution, and preventing pandemics. One …

Cas9-based technologies have transformed genome engineering and the interrogation of
genomic functions, but methods to control such technologies across numerous dimensions …

Posttranslational modifications alter the biophysical properties of proteins and thereby
influence cellular physiology. One emerging manner by which such modifications regulate …

Drug‐induced proteome stress that involves protein aggregation may cause adverse effects
and undermine the safety profile of a drug. Safety of drugs is regularly evaluated using …

Stress induced amorphous proteome aggregation is a hallmark for diseased cells, with the
proteomic composition intimately associated with disease pathogenicity. Due to its …

The role of stress-induced increases in SUMO2/3 conjugation during the heat shock
response (HSR) has remained enigmatic. We investigated SUMO signal transduction at the …

CCT251236 1, a potent chemical probe, was previously developed from a cell-based
phenotypic high-throughput screen (HTS) to discover inhibitors of transcription mediated by …

Protein folding in the cell is mediated by an extensive network of> 1,000 chaperones, quality
control factors, and trafficking mechanisms collectively termed the proteostasis network …

Phenotypic screens, which focus on measuring and quantifying discrete cellular changes
rather than affinity for individual recombinant proteins, have recently attracted renewed …