Protein–protein interactions: switch from classical methods to proteomics and bioinformatics-based approaches

AG Ngounou Wetie, I Sokolowska, AG Woods… - Cellular and molecular …, 2014 - Springer
Following the sequencing of the human genome and many other organisms, research on
protein-coding genes and their functions (functional genomics) has intensified …

Investigation of stable and transient protein–protein interactions: past, present, and future

AG Ngounou Wetie, I Sokolowska, AG Woods… - …, 2013 - Wiley Online Library
This article presents an overview of the literature and a review of recent advances in the
analysis of stable and transient protein–protein interactions (PPI s) with a focus on their …

Proteomics-based identification of dysregulated proteins in breast cancer

AN Neagu, M Jayathirtha, D Whitham, P Mutsengi… - Proteomes, 2022 - mdpi.com
Immunohistochemistry (IHC) is still widely used as a morphology-based assay for in situ
analysis of target proteins as specific tumor antigens. However, as a very heterogeneous …

A pilot proteomic analysis of salivary biomarkers in autism spectrum disorder

AG Ngounou Wetie, KL Wormwood, S Russell… - Autism …, 2015 - Wiley Online Library
Autism spectrum disorder (ASD) prevalence is increasing, with current estimates at 1/68–
1/50 individuals diagnosed with an ASD. Diagnosis is based on behavioral assessments …

Proteomic analysis of plasma membranes isolated from undifferentiated and differentiated HepaRG cells

I Sokolowska, C Dorobantu, AG Woods, A Macovei… - Proteome science, 2012 - Springer
Liver infection with hepatitis B virus (HBV), a DNA virus of the Hepadnaviridae family, leads
to severe disease, such as fibrosis, cirrhosis and hepatocellular carcinoma. The early steps …

Identification of posttranslational modifications (PTMs) of proteins by mass spectrometry

R Aslebagh, KL Wormwood… - Advancements of mass …, 2019 - Springer
There are only 30,000 human genes, which, according to the central dogma from biology, it
means that there should be 30,000 mRNA and 30,000 proteins. However, there are at least …

Methods to investigate the secretome of senescent cells

A Samiminemati, D Aprile, D Siniscalco… - Methods and …, 2024 - mdpi.com
The word “secretome” was first used to describe the proteins that cells secrete under
different circumstances; however, recent studies have proven the existence of other …

Cancer secretomes and their place in supplementing other hallmarks of cancer

S Patel, AGN Wetie, CC Darie, BD Clarkson - Advancements of mass …, 2014 - Springer
The secretome includes all macromolecules secreted by cells, in particular conditions at
defined times, allowing cell–cell communication. Cancer cell secretomes that are altered …

The importance of diet-related effects of the antibiotic ciprofloxacin on the leaf-shredding invertebrate Gammarus fossarum (Crustacea; Amphipoda)

M Konschak, JP Zubrod, P Baudy, P Fink, K Kenngott… - Aquatic Toxicology, 2020 - Elsevier
Antibiotics may constitute a risk for aquatic detritivorous macroinvertebrates (ie, shredders)
via waterborne and dietary antibiotic exposure. In addition, antibiotics can alter the food …

Salivary proteomics and biomarkers in neurology and psychiatry

KL Wormwood, R Aslebagh… - PROTEOMICS …, 2015 - Wiley Online Library
Biomarkers are greatly needed in the fields of neurology and psychiatry, to provide objective
and earlier diagnoses of CNS conditions. Proteomics and other omics MS‐based …