In the mouse, naïve pluripotent stem cells (PSCs) are thought to represent the cell culture
equivalent of the late epiblast in the pre-implantation embryo, with which they share a …

In vitro stem cell models that replicate human gastrulation have been generated, but they
lack the essential extraembryonic cells needed for embryonic development, morphogenesis …

Understanding the progression of early human embryonic development prior to implantation
is of fundamental biological importance. Greater insights into early developmental events …

Totipotency is the ability of a single cell to give rise to all of the differentiated cell types that
build the conceptus, yet how to capture this property in vitro remains incompletely …

Recently, several studies using cultures of human embryos together with single-cell RNA-
seq analyses have revealed differences between humans and mice, necessitating the study …

Early mammalian embryogenesis is controlled by mechanisms governing the balance
between pluripotency and differentiation. The expression of early lineage-specific genes can …

De novo mutations in ADNP, which encodes activity-dependent neuroprotective protein
(ADNP), have recently been found to underlie Helsmoortel–Van der Aa syndrome, a …

Fate-determining transcription factors (TFs) can promote lineage-restricted transcriptional
programs from common progenitor states. The inner cell mass (ICM) of mouse blastocysts co …

Transcription factor-mediated reprograming is a powerful method to study cell fate changes.
In this study, we demonstrate that the transcription factor Gata6 can initiate reprograming of …

Abstract The Bone Morphogenetic Protein (BMP) signaling pathway has established roles in
early embryonic morphogenesis, particularly in the epiblast. More recently, however, it has …