Stimulus-cleavable chemistry in the field of controlled drug delivery

Y Xue, H Bai, B Peng, B Fang, J Baell, L Li… - Chemical Society …, 2021 - pubs.rsc.org
Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention
owing to their capability of achieving exquisite control over drug release via the exposure to …

Looking back: a short history of the discovery of enzymes and how they became powerful chemical tools

CM Heckmann, F Paradisi - ChemCatChem, 2020 - Wiley Online Library
Enzymatic approaches to challenges in chemical synthesis are increasingly popular and
very attractive to industry given their green nature and high efficiency compared to traditional …

Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme

A Warshel, M Levitt - Journal of molecular biology, 1976 - Elsevier
A general method for detailed study of enzymic reactions is presented. The method
considers the complete enzyme-substrate complex together with the surrounding solvent …

Selforganization of matter and the evolution of biological macromolecules

M Eigen - Naturwissenschaften, 1971 - Springer
The question about the origin of life often appears as a question about" cause and effect".
Physical theories of macroscopic processes usually involve answers to such questions …

Serine protease mechanism and specificity

L Hedstrom - Chemical reviews, 2002 - ACS Publications
Almost one-third of all proteases can be classified as serine proteases, named for the
nucleophilic Ser residue at the active site. This mechanistic class was originally …

The anatomy and taxonomy of protein structure

JS Richardson - Advances in protein chemistry, 1981 - Elsevier
Publisher Summary This chapter investigates the anatomy and taxonomy of protein
structures. A protein is a polypeptide chain made up of amino acid residues linked together …

The structural basis of ribosome activity in peptide bond synthesis

P Nissen, J Hansen, N Ban, PB Moore, TA Steitz - Science, 2000 - science.org
Using the atomic structures of the large ribosomal subunit from Haloarcula marismortui and
its complexes with two substrate analogs, we establish that the ribosome is a ribozyme and …

Acetylcholinesterase: enzyme structure, reaction dynamics, and virtual transition states

DM Quinn - Chemical reviews, 1987 - ACS Publications
College, Quincy, IL. His graduate work in physical organic chemistry under Richard L.
Schowen of the University of Kansas Chemistry Department culminated in a Ph. D. degree in …

[HTML][HTML] Structure and function of legumain in health and disease

E Dall, H Brandstetter - Biochimie, 2016 - Elsevier
The last years have seen a steady increase in our understanding of legumain biology that is
driven from two largely uncoupled research arenas, the mammalian and the plant legumain …

[图书][B] Enzymes

M Dixon, EC Webb - 1960 - books.google.com
Page 1 The Enzymes THIRD EDITION Edited by Paul D. Boyer X Protein Synthesis DNA
Synthesis and Repair RNA Synthesis Energy-Linked ATPases Synthetases Page 2 The …