Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate
vast protein diversity from a limited number of genes. The mechanisms and outcomes of …

Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease
(AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system …

Recent studies have suggested that lymphatics help to restore heart function after cardiac
injury,,,,–. Here we report that lymphatics promote cardiac growth, repair and …

This review critically summarizes the neuropathology and genetics of schizophrenia, the
relationship between them, and speculates on their functional convergence. The …

During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …

AKT-GSK3β signaling is a target of lithium and as such has been implicated in the
pathogenesis of mood disorders. Here, we provide evidence that this signaling pathway also …

Over the last 50 years, the reeler mutant mouse has become an important model for studying
normal and abnormal development in the cerebral cortex and other regions of the brain …

Reelin is a glycoprotein that serves important roles both during development (regulation of
neuronal migration and brain lamination) and in adulthood (maintenance of synaptic …

The intrigue of lithium, the simplest drug in the modern pharmacopoeia, extends from its
complex actions in cells to its therapeutic effects as a mood stabilizer. New surprises from …

The microtubule-associated protein tau, abundant in neurons, has gained notoriety due to
the fact that it is deposited in cells as fibrillar lesions in numerous neurodegenerative …