Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy

HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
Oxidative stress is a component of many diseases, including atherosclerosis, chronic
obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small …

Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease

R Bai, J Guo, XY Ye, Y Xie, T Xie - Ageing research reviews, 2022 - Elsevier
As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering
to their families and causes a heavy socioeconomic burden to society. A vast amount of …

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

F Ursini, M Maiorino - Free Radical Biology and Medicine, 2020 - Elsevier
Ferroptosis (FPT) is a form of cell death due to missed control of membrane lipid
peroxidation (LPO). According to the axiomatic definition of non-accidental cell death, LPO …

Antioxidants: Classification, natural sources, activity/capacity measurements, and usefulness for the synthesis of nanoparticles

J Flieger, W Flieger, J Baj, R Maciejewski - Materials, 2021 - mdpi.com
Natural extracts are the source of many antioxidant substances. They have proven useful not
only as supplements preventing diseases caused by oxidative stress and food additives …

The effects of polyphenols and other bioactives on human health

CG Fraga, KD Croft, DO Kennedy… - Food & function, 2019 - pubs.rsc.org
Although deficiencies in polyphenol intake do not result in specific deficiency diseases,
adequate intake of polyphenols could confer health benefits, especially with regard to …

RONS and oxidative stress: An overview of basic concepts

AK Aranda-Rivera, A Cruz-Gregorio… - Oxygen, 2022 - mdpi.com
Oxidative stress (OS) has greatly interested the research community in understanding
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …

Revisiting the oxidation of flavonoids: Loss, conservation or enhancement of their antioxidant properties

H Speisky, F Shahidi, A Costa de Camargo, J Fuentes - Antioxidants, 2022 - mdpi.com
Flavonoids display a broad range of health-promoting bioactivities. Among these, their
capacity to act as antioxidants has remained most prominent. The canonical reactive oxygen …

[HTML][HTML] 13 reasons why the brain is susceptible to oxidative stress

JN Cobley, ML Fiorello, DM Bailey - Redox biology, 2018 - Elsevier
The human brain consumes 20% of the total basal oxygen (O 2) budget to support ATP
intensive neuronal activity. Without sufficient O 2 to support ATP demands, neuronal activity …

The impact of oxidative stress in human pathology: Focus on gastrointestinal disorders

R Vona, L Pallotta, M Cappelletti, C Severi… - Antioxidants, 2021 - mdpi.com
Accumulating evidence shows that oxidative stress plays an essential role in the
pathogenesis and progression of many diseases. The imbalance between the production of …

Antioxidant activity, total phenolics and flavonoids contents: Should we ban in vitro screening methods?

D Granato, F Shahidi, R Wrolstad, P Kilmartin… - Food chemistry, 2018 - Elsevier
As many studies are exploring the association between ingestion of bioactive compounds
and decreased risk of non-communicable diseases, the scientific community continues to …