[HTML][HTML] IgG4 antibodies induced by repeated vaccination may generate immune tolerance to the SARS-CoV-2 spike protein

VN Uversky, EM Redwan, W Makis, A Rubio-Casillas - Vaccines, 2023 - mdpi.com
Less than a year after the global emergence of the coronavirus SARS-CoV-2, a novel
vaccine platform based on mRNA technology was introduced to the market. Globally, around …

[HTML][HTML] Viral proteases as therapeutic targets

T Majerová, J Konvalinka - Molecular Aspects of Medicine, 2022 - Elsevier
Some medically important viruses―including retroviruses, flaviviruses, coronaviruses, and
herpesviruses―code for a protease, which is indispensable for viral maturation and …

[HTML][HTML] SARS-CoV-2: a master of immune evasion

A Rubio-Casillas, EM Redwan, VN Uversky - Biomedicines, 2022 - mdpi.com
Viruses and their hosts have coevolved for a long time. This coevolution places both the
pathogen and the human immune system under selective pressure; on the one hand, the …

[HTML][HTML] Roadmap for focused ion beam technologies

K Höflich, G Hobler, FI Allen, T Wirtz, G Rius… - Applied Physics …, 2023 - pubs.aip.org
The focused ion beam (FIB) is a powerful tool for fabrication, modification, and
characterization of materials down to the nanoscale. Starting with the gallium FIB, which was …

Intravital imaging of three different microvascular beds in SARS-CoV-2–infected mice

FVS Castanheira, R Nguyen, M Willson… - Blood …, 2023 - ashpublications.org
Severe acute respiratory syndrome coronavirus–2 (SARS-CoV-2) enters the respiratory
tract, where it infects the alveoli epithelial lining. However, patients have sequelae that …

[HTML][HTML] Does SARS-CoV-2 induce IgG4 synthesis to evade the immune system?

A Rubio-Casillas, EM Redwan, VN Uversky - Biomolecules, 2023 - mdpi.com
SARS-CoV-2, the virus that causes the COVID-19 disease, has been shown to cause
immune suppression in certain individuals. This can manifest as a reduced ability of the …

[HTML][HTML] The Control of Metabolic CO2 in Public Transport as a Strategy to Reduce the Transmission of Respiratory Infectious Diseases

M Baselga, JJ Alba, AJ Schuhmacher - International Journal of …, 2022 - mdpi.com
The global acceptance of the SARS-CoV-2 airborne transmission led to prevention
measures based on quality control and air renewal. Among them, carbon dioxide (CO2) …

[HTML][HTML] Non-Classical Intercellular Communications: Basic Mechanisms and Roles in Biology and Medicine

N Polyakova, M Kalashnikova, A Belyavsky - International Journal of …, 2023 - mdpi.com
In multicellular organisms, interactions between cells and intercellular communications form
the very basis of the organism's survival, the functioning of its systems, the maintenance of …

[HTML][HTML] SARS-CoV-2 Omicron Subvariants Balance Host Cell Membrane, Receptor, and Antibody Docking via an Overlapping Target Site

M Overduin, RK Bhat, TA Kervin - Viruses, 2023 - mdpi.com
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are emerging
rapidly and offer surfaces that are optimized for recognition of host cell membranes while …

Leishmania donovani Exploits Tunneling Nanotubes for Dissemination and Propagation of B Cell Activation

T Stögerer, S Silva-Barrios… - Microbiology …, 2023 - Am Soc Microbiol
Polyclonal B cell activation and the resulting hypergammaglobulinemia are a detrimental
consequence of visceral leishmaniasis (VL); however, the mechanisms underlying this …