Dysregulation of the epigenome drives aberrant transcriptional programmes that promote
cancer onset and progression. Although defective gene regulation often affects oncogenic …

Epidemiological evidence indicates that regular physical activity and/or frequent structured
exercise reduces the incidence of many chronic diseases in older age, including …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Natural killer (NK) cells provide protection against infectious pathogens and cancer. For
decades it has been appreciated that two major NK cell subsets (CD56 bright and CD56 …

From a technical point of view a flow cytometer is a light detection device capable of
detecting photons of different wavelengths over a high dynamic range. In order to achieve a …

Natural killer (NK) cells contribute to the first line of defense against viruses and to the
control of tumor growth and metastasis spread. The discovery of HLA class I specific …

Natural killer (NK) cells are critical to both innate and adaptive immunity. However, the
development and heterogeneity of human NK cells are yet to be fully defined. Using single …

Major advances in preventing, delaying, or curing individual pathologies are responsible for
an increasingly long life span in the developed parts of our planet, and indeed reaching …

Background Programmed death 1 (PD-1) is an immunologic checkpoint that limits immune
responses by delivering potent inhibitory signals to T cells on interaction with specific …

Recent studies have demonstrated the potential of natural killer (NK) cells in immunotherapy
to treat multiple types of cancer. NK cells are innate lymphoid cells that play essential roles …