Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Maintenance of skeletal muscle mass is regulated by the balance between anabolic and
catabolic processes. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved …

The loss of muscle mass and strength with aging results in significant functional impairment.
Creatine supplementation has been used in combination with resistance training as a …

Ageing is influenced by the intrinsic disposition delineating what is maximally possible and
extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic …

AMP-activated protein kinase (AMPK) is a fundamental regulator of energy metabolism,
stress resistance, and cellular proteostasis. AMPK signaling controls an integrated signaling …

Physical activity and molecular ageing presumably interact to precipitate musculoskeletal
decline in humans with age. Herein, we have delineated molecular networks for these two …

Resistance exercise training (RET) remains the most effective treatment for the loss of
muscle mass and strength in elderly people. However, the underlying cellular and molecular …

Healthy individuals maintain remarkably constant skeletal muscle mass across much of
adult life, suggesting the existence of robust homeostatic mechanisms. Muscle exists in …

The rate of muscle loss with aging is higher in men than women. However, women have
smaller muscles throughout the adult life. Protein content is a major determinant of skeletal …

Physical activity, including walking, has numerous health benefits in older adults, supported
by a plethora of observational and interventional studies. Walking decreases the risk or …