Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic
factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating …

Transforming growth factor‐β (TGF‐β) is a proinflammatory cytokine known to control a
diverse array of pathological and physiological conditions during normal development and …

G protein–coupled receptors (GPCRs) are well known to signal via cyclic AMP (cAMP)
production at the plasma membrane, but it is now clear that various GPCRs also signal after …

The stability and membrane localization of the transforming growth factor-β (TGF-β) type I
receptor (TβRI) determines the levels of TGF-β signalling. TβRI is targeted for ubiquitylation …

Nodal-related ligands of the transforming growth factor-beta (TGFβ) superfamily play central
roles in patterning the early embryo during the induction of mesoderm and endoderm and …

TGFβ signaling controls diverse normal developmental processes and pathogenesis of
diseases including cancer and autoimmune and fibrotic diseases. TGFβ responses are …

Transforming growth factor-β (TGF-β) regulates cell proliferation, differentiation and
apoptosis, and TGF-β-related proteins have key roles in development, tissue homeostasis …

TGF-β signaling regulates diverse cellular processes, including cell proliferation,
differentiation, apoptosis, cell plasticity and migration. Its dysfunctions can result in various …

The basic vertebrate body plan of the zebrafish embryo is established in the first 10 hours of
development. This period is characterized by the formation of the anterior-posterior and …

Nodal signals belong to the TGF-β superfamily and are essential for the induction of
mesoderm and endoderm and the determination of the left–right axis. Nodal signals can act …