Designer drugs: mechanism of action and adverse effects

D Luethi, ME Liechti - Archives of toxicology, 2020 - Springer
Psychoactive substances with chemical structures or pharmacological profiles that are
similar to traditional drugs of abuse continue to emerge on the recreational drug market …

Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly

P Pacher, S Steffens, G Haskó, TH Schindler… - Nature Reviews …, 2018 - nature.com
Dysregulation of the endogenous lipid mediators endocannabinoids and their G-protein-
coupled cannabinoid receptors 1 and 2 (CB1R and CB2R) has been implicated in a variety …

Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications

MS Castaneto, DA Gorelick, NA Desrosiers… - Drug and alcohol …, 2014 - Elsevier
Background Synthetic cannabinoids (SC) are a heterogeneous group of compounds
developed to probe the endogenous cannabinoid system or as potential therapeutics …

A systematic review of adverse events arising from the use of synthetic cannabinoids and their associated treatment

RJ Tait, D Caldicott, D Mountain, SL Hill… - Clinical …, 2016 - Taylor & Francis
Abstract Context: Synthetic cannabinoids (SCs) such as “Spice”,“K2”, etc. are widely
available via the internet despite increasing legal restrictions. Currently, the prevalence of …

The synthetic cannabinoids phenomenon: from structure to toxicological properties. A review

VL Alves, JL Gonçalves, J Aguiar… - Critical Reviews in …, 2020 - Taylor & Francis
The word “cannabinoid” refers to every chemical substance, regardless of structure or origin,
that joins the cannabinoid receptors of the body and brain and that have similar effects to …

Novel psychoactive substances of interest for psychiatry

F Schifano, L Orsolini, G Duccio Papanti… - World …, 2015 - Wiley Online Library
Novel psychoactive substances include synthetic cannabinoids, cathinone derivatives,
psychedelic phenethylamines, novel stimulants, synthetic opioids, tryptamine derivatives …

Synthetic cannabinoids

B Mills, A Yepes, K Nugent - The American journal of the medical sciences, 2015 - Elsevier
Synthetic cannabinoids (SCBs), also known under the brand names of “Spice,”“K2,”“herbal
incense,”“Cloud 9,”“Mojo” and many others, are becoming a large public health concern due …

Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ9-THC: mechanism underlying greater toxicity?

WE Fantegrossi, JH Moran, A Radominska-Pandya… - Life sciences, 2014 - Elsevier
K2 or Spice products are emerging drugs of abuse that contain synthetic cannabinoids
(SCBs). Although assumed by many teens and first time drug users to be a “safe” and “legal” …

The adverse health effects of synthetic cannabinoids with emphasis on psychosis-like effects

J Van Amsterdam, T Brunt… - Journal of …, 2015 - journals.sagepub.com
Cannabis use is associated with an increased risk of psychosis in vulnerable individuals.
Cannabis containing high levels of the partial cannabinoid receptor subtype 1 (CB1) agonist …

Comprehensive review of the detection methods for synthetic cannabinoids and cathinones

A Namera, M Kawamura, A Nakamoto, T Saito… - Forensic toxicology, 2015 - Springer
A number of N-alkyl indole or indazole-3-carbonyl analogs, with modified chemical
structures, are distributed throughout the world as synthetic cannabinoids. Like synthetic …