Membranes of mammalian subcellular organelles contain defined amounts of specific
phospholipids that are required for normal functioning of proteins in the membrane. Despite …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Lipids were long considered to be passive passengers of carrier vesicles with the single role
of sealing the transport container. We now know that specific phospholipids are required for …

Phosphatidylinositol (PtdIns) transfer proteins (PITPs) regulate signaling interfaces between
lipid metabolism and membrane trafficking. Herein, we demonstrate that AtSfh1p, a member …

Genetic variants that increase the risk of fatty liver disease and cirrhosis have recently been
identified in the proximity of membrane-bound O-acyltransferase domain-containing 7 …

Cellular lipids are composed of linear combinations of aliphatic chains covalently attached
to backbones and/or head groups that collectively represent the cellular lipidome. Herein we …

Research in nonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis
(NASH), has been limited by the availability of suitable models for this disease. A number of …

Phosphoinositides are key regulators of a large number of diverse cellular processes that
include membrane trafficking, plasma membrane receptor signaling, cell proliferation, and …

Lipids are amphiphilic molecules that self-assemble to form biological membranes.
Thousands of lipid species coexist in the cell and, once combined, define organelle identity …

Summary Phosphatidylinositol (PtdIns) transfer proteins (PITPs) stimulate PtdIns-4-P
synthesis and signaling in eukaryotic cells, but to what biological outcomes such signaling …