Sphingomyelin (SM) is a dominant sphingolipid in membranes of mammalian cells and this
lipid class is specifically enriched in the plasma membrane, the endocytic recycling …

Biological membranes, primarily composed of lipids, envelop each living cell. The intricate
composition and organization of membrane lipids, including the variety of fatty acids they …

Proteins and RNA can phase separate from the aqueous cellular environment to form
subcellular compartments called condensates. This process results in a protein–RNA …

Polyunsaturated fatty acids (PUFAs), reported to be cytotoxic at micromolar concentrations
for cancer cells in vitroand in vivo, are currently being tested in clinical trials as anti‐cancer …

The presence of phospholipids as a component of chromatin is now well documented and
many enzymes such as sphingomyelinase, sphingomyelin-synthase, reverse sphingomyelin …

We investigated nuclear neutral-lipid (NL) composition and organization, as NL may
represent an alternative source for providing fatty acids and cholesterol (C) to membranes …

The amphipathic helical (AH) membrane binding motif is recognized as a major device for
lipid compositional sensing [1]. We explore the function and mechanism of sensing by the …

Sphingolipids are most prominently expressed in the plasma membrane, but recent studies
have pointed to important signaling and regulatory roles in the nucleus. The most abundant …

The four main types of biomolecules are nucleic acids, proteins, carbohydrates and lipids.
The knowledge about their respective interactions is as important as the individual …

Nuclear lipid metabolism is implicated in various processes, including transcription, splicing,
and DNA repair. Sphingolipids play roles in numerous cellular functions, and an emerging …