Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review

P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

A review of biomedical datasets relating to drug discovery: a knowledge graph perspective

S Bonner, IP Barrett, C Ye, R Swiers… - Briefings in …, 2022 - academic.oup.com
Drug discovery and development is a complex and costly process. Machine learning
approaches are being investigated to help improve the effectiveness and speed of multiple …

[图书][B] Imagining the Internet: Communication, innovation, and governance

R Mansell - 2012 - books.google.com
This book is an impressive survey of our collective and cumulative understanding of the
evolution of digital communication systems and the Internet. Whilst the information societies …

Network embedding in biomedical data science

C Su, J Tong, Y Zhu, P Cui, F Wang - Briefings in bioinformatics, 2020 - academic.oup.com
Owning to the rapid development of computer technologies, an increasing number of
relational data have been emerging in modern biomedical research. Many network-based …

Chem2Bio2RDF: a semantic framework for linking and data mining chemogenomic and systems chemical biology data

B Chen, X Dong, D Jiao, H Wang, Q Zhu, Y Ding… - BMC …, 2010 - Springer
Background Recently there has been an explosion of new data sources about genes,
proteins, genetic variations, chemical compounds, diseases and drugs. Integration of these …

Unraveling human complexity and disease with systems biology and personalized medicine

S Naylor, JY Chen - Personalized medicine, 2010 - Taylor & Francis
We are all perplexed that current medical practice often appears maladroit in curing our
individual illnesses or disease. However, as is often the case, a lack of understanding, tools …

Matrix factorization for biomedical link prediction and scRNA-seq data imputation: an empirical survey

L Ou-Yang, F Lu, ZC Zhang, M Wu - Briefings in Bioinformatics, 2022 - academic.oup.com
Advances in high-throughput experimental technologies promote the accumulation of vast
number of biomedical data. Biomedical link prediction and single-cell RNA-sequencing …

Drug knowledge bases and their applications in biomedical informatics research

Y Zhu, O Elemento, J Pathak… - Briefings in bioinformatics, 2019 - academic.oup.com
Recent advances in biomedical research have generated a large volume of drug-related
data. To effectively handle this flood of data, many initiatives have been taken to help …

Semantic web meets integrative biology: a survey

H Chen, T Yu, JY Chen - Briefings in bioinformatics, 2013 - academic.oup.com
Integrative Biology (IB) uses experimental or computational quantitative technologies to
characterize biological systems at the molecular, cellular, tissue and population levels. IB …

Proteogenomic convergence for understanding cancer pathways and networks

ES Boja, H Rodriguez - Clinical proteomics, 2014 - Springer
During the past several decades, the understanding of cancer at the molecular level has
been primarily focused on mechanisms on how signaling molecules transform …