Although glutamate is one of the most important excitatory neurotransmitters of the central
nervous system, its excessive extracellular concentration leads to uncontrolled continuous …

In the last two decades, there has been increasing evidence supporting non-neuronal cells
as active contributors to neurodegenerative disorders. Among glial cells, astrocytes play a …

Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7)
results in an antidepressant phenotype in mice. However, the link between the deficiency of …

BACKGROUND: Sleep deprivation (wake therapy) provides rapid clinical relief in many
patients with major depressive disorder (MDD). Changes in glutamatergic …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
progressive degeneration of motor neurons (MNs). Astrocytes display a toxic phenotype in …

Abstract Metabotropic glutamate-5 receptors (mGluR5), which physically and functionally
interact with N-methyl-d-Aspartate (NMDA) receptors, likewise control cognitive processes …

The metabotropic glutamate (mGlu) receptor, mGlu5, is of particular relevance for
hippocampal function. It is critically required for the expression of long-term potentiation …

Substantial evidence reveals that prenatal stress is closely linked with abnormal behavior in
offspring, but the mechanism remains unclear. In this study, our aim was to observe the …

Metabotropic glutamate receptors (mGluRs) were previously shown to modulate several
essential functions in glial cells, including cell proliferation, glutamate uptake, neurotrophic …

Lithium (Li) is the main mood stabilizer and acts on multiple biochemical targets, leading to
neuronal plasticity. Several clinical studies have shown that tamoxifen (TMX)–a protein …