Congenital myasthenic syndromes (CMS) are a heterogeneous group of disorders
characterized by impaired neuromuscular signal transmission due to germline pathogenic …

Throughout the nervous system, moment-to-moment communication relies on postsynaptic
receptors to detect neurotransmitters and change the membrane potential. For the Cys-loop …

Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic
members of the ligand‐gated ion‐channel superfamily, which has precursors in the …

Nicotinic ACh receptors (nAChRs) can undergo desensitization, a reversible reduction in
response during sustained agonist application. Although the mechanism of desensitization …

Orthologs of the pentameric receptor channels that mediate fast synaptic transmission in the
central and peripheral nervous systems have been found in several bacterial species and in …

France rather than the tertiary folding within each individual subunit. In other words, the
cooperative interactions The concept of allosteric proteins was initially proposed between …

The synapse is a localized neurohumoral contact between a neuron and an effector cell and
may be considered the quantum of fast intercellular communication. Analogously, the …

Congenital myasthenic syndromes (CMSs) stem from genetic defects in endplate (EP)-
specific presynaptic, synaptic, and postsynaptic proteins. The postsynaptic CMSs identified …

Congenital myasthenic syndromes (CMS) are clinically and genetically heterogeneous
inherited disorders characterized by impaired neuromuscular transmission. Mutations in the …

The rate constants of acetylcholine receptor channels (AChR) desensitization and recovery
were estimated from the durations and frequencies of clusters of single-channel currents …