After the discovery of zinc deficiency in the 1960s, it soon became clear that zinc is essential
for the function of the immune system. Zinc ions are involved in regulating intracellular …

Major Depressive Disorder (MDD) is a leading cause of disability worldwide, creating a high
medical and socioeconomic burden. There is a growing interest in the biological …

Depression is one of the leading health problems, and> 300 million people have a major
depressive disorder and this number is getting increasing. Depression complicates the …

Zinc is the second abundant trace element in the human central nervous system (CNS). Zinc
homeostasis is impaired in the elderly population and Alzheimer's disease (AD) patients …

Objectives Melancholia is a severe form of depression that is typified by greater genetic and
biological influence, distinct symptomatology, and preferential response to physical …

This narrative review was conducted using searches of the PubMed/Medline and Google
Scholar databases from inception to November 2019. Clinical trials and relevant articles …

The multifactorial etiology of major depressive disorder (MDD) includes biological,
environmental, genetic, and psychological aspects. Recently, there has been an increasing …

To examine immune-inflammatory and oxidative (I&O) biomarkers in major depression
(MDD) and its related phenotypes, we recruited 114 well-phenotyped depressed patients …

Given the moderate efficacy of the currently available antidepressants (ADs) in the treatment
of major depressive disorder (MDD), the identification of agents that are both able to …

Zinc is an essential trace metal for bacteria of the intestinal flora. Approximately 20% of
dietary zinc–intake is used by intestinal bacteria. The microbiome has recently been …