Multicomponent reactions (MCRs) are powerful synthetic tools in which more than two
starting materials couple with each other to form multi-functionalized compounds in a one …

Cancer, more than any other human disease, now has a surfeit of potential molecular targets
poised for therapeutic exploitation. Currently, a number of attractive and validated cancer …

Pyridone core structure has attracted much attention due to its abundance in natural
products of biological importance. 2-Pyridone derivatives display diverse biological …

Photoredox catalysis in water has been receiving increasing attention due to its merits of
being environment friendly, inexpensive, and safe. However, efficient approaches to …

Abstract A new series of 1, 2, 4-oxadiazole incorporated indazole-isoxazole (12a–j)
derivatives were designed, synthesized and confirmed their structures by 1HNMR, 13CNMR …

Ru (II)-Catalyzed C6 site-selective amidation of 2-pyridones with 1, 4, 2-dioxazol-5-ones has
been developed. The reaction occurred with a low catalyst loading and broad substrate …

Overexpression of protein tyrosine phosphatase PTP4A oncoproteins is common in many
human cancers and is associated with poor patient prognosis and survival. We observed …

The phosphatase PTP4A3 is an attractive anticancer target, but knowledge of its exact role
in cells remains incomplete. A potent, structurally novel inhibitor of the PTP4A family was …

To identify pore domain ligands on Kv7. 2 potassium ion channels, we compared wild-type
(WT) and W236L mutant Kv7. 2 channels in a series of assays with previously validated and …

Protein tyrosine phosphatases (PTPs) undeniably have a central role in the development
and progression of human cancers. Historically, however, PTPs have not been viewed as …