PURPOSE OF REVIEW Early-onset Alzheimer disease (AD) is defined as having an age of
onset younger than 65 years. While early-onset AD is often overshadowed by the more …

Alzheimer disease (AD) originally meant a disorder of early-onset (EOAD;< 65 years of age)
and did not include older patients with “senile dementia.” In fact, the first patient reported …

Alzheimer's disease (AD) is an irredeemable chronic neurodegenerative disorder and the
predominant cause of dementia. The disease progression is associated with the deposition …

Synapse loss strongly correlates with cognitive decline in Alzheimer's disease (AD), but the
underlying mechanisms are poorly understood. Deficient Wnt signaling contributes to …

Background We aimed to determine the effects and tolerability of repetitive transcranial
magnetic stimulation (rTMS) on apathy in patients with neurodegenerative conditions, mild …

Abstract Background Early-onset Alzheimer's disease (EOAD) is characterized by young
age of onset (< 65 years), severe neurodegeneration, and rapid disease progression, thus …

Alzheimer's disease (AD) is the most common form of neurodegenerative disease. The
predominant characteristics of AD are the accumulation of amyloid-β (Aβ) and …

Abstract Objective The Longitudinal Early‐Onset Alzheimer's Disease Study (LEADS) seeks
to provide comprehensive understanding of early‐onset Alzheimer's disease (EOAD; onset< …

Objective: Predicted age difference (PAD) is a score computed by subtracting chronological
age from “brain” age, which is estimated using neuroimaging data. The goal of this study …

Болезнь Альцгеймера (БА)-наиболее распространенная причина когнитивных
нарушений у взрослых. Выделяют две основные формы БА: с ранним началом (дебют …