The discovery of microRNAs (miRNAs) has added a new player to the regulation of gene
expression. With the increasing number of molecular species involved in gene regulatory …

The insulin signaling pathway is composed of a large number of molecules that positively or
negatively modulate insulin specific signal transduction following its binding to the cognate …

MicroRNAs (miRNAs) are rapidly emerging as central regulators of gene expression in the
postnatal mammalian brain. Initial studies mostly focused on the function of specific miRNAs …

During miRNA biogenesis, the microprocessor complex (MC), which is composed minimally
of Drosha, an RNase III enzyme, and DGCR8, a double-stranded RNA-binding protein …

MicroRNAs (miRNAs) are a ubiquitous component of gene regulatory networks that
modulate the precise amounts of proteins expressed in a cell. Despite their small size …

The ribonuclease III enzyme Drosha has a central role in the biogenesis of microRNA
(miRNA) by binding and cleaving hairpin structures in primary RNA transcripts into precursor …

The molecular basis of astrocyte differentiation and maturation is poorly understood. As
micro RNA s have important roles in cell fate transitions, we set out to study their function …

Dysregulation of miRNA expression has been associated with many cardiovascular
diseases in animal models, as well as in patients. In the present review, we summarize …

Cellular stress, combined with dysfunctional, inadequate mitochondrial phosphorylation,
produces an excessive amount of reactive oxygen species (ROS) and an increased level of …

In the brain, the connection between sensory information triggered by the presence of a
stressor and the organism's reaction involves limbic areas such as the hippocampus …