Polycomb group complexes, which are known to regulate homeotic genes, have now been
found to control hundreds of other genes in mammals and insects. First believed to …

In development, cells pass on established gene expression patterns to daughter cells over
multiple rounds of cell division. The cellular memory of the gene expression state is termed …

Propagation of gene-expression patterns through the cell cycle requires the existence of an
epigenetic mark that re-establishes the chromatin architecture of the parental cell in the …

Polycomb (PcG) complexes maintain the silent state of target genes. The mechanism of
silencing is not known but has been inferred to involve chromatin packaging to block the …

Polycomb group response elements (PREs) play an essential role in gene regulation by the
Polycomb group (PcG) repressor proteins in Drosophila. PREs are required for the …

cis-Regulatory DNA elements contain multiple binding sites for activators and repressors of
transcription. Among these elements are enhancers, which establish gene expression …

Cis-regulatory sequences direct patterns of gene expression essential for development and
physiology. Evolutionary changes in these sequences contribute to phenotypic divergence …

Abstract The homeotic Abdominal-B (Abd-B) gene expression depends on a modular cis-
regulatory region divided into discrete functional domains (iab) that control the expression of …

Ultraconserved elements (UCEs) are discrete genomic elements conserved across large
evolutionary distances. Although UCEs have been linked to multiple facets of mammalian …

Chromatin cross-linking is widely used for mapping the distribution of chromosomal proteins
by immunoprecipitation, but our knowledge of the physical properties of chromatin …