Protein nanoparticles for Pickering emulsions: A comprehensive review on their shapes, preparation methods, and modification methods

T Zhang, J Xu, J Chen, Z Wang, X Wang… - Trends in Food Science & …, 2021 - Elsevier
Background Protein nanoparticles are promising candidates for the preparation and
stabilization of Pickering emulsions. The research and development of protein nanoparticles …

Pulsed electric field: Fundamentals and effects on the structural and techno-functional properties of dairy and plant proteins

A Taha, F Casanova, P Šimonis, V Stankevič… - Foods, 2022 - mdpi.com
Dairy and plant-based proteins are widely utilized in various food applications. Several
techniques have been employed to improve the techno-functional properties of these …

Formulation, structure, and applications of therapeutic and amino acid-based deep eutectic solvents: An overview

MS Rahman, R Roy, B Jadhav, MN Hossain… - Journal of Molecular …, 2021 - Elsevier
In the design of greener chemicals, deep eutectic solvents (DESs) are considered as one of
the most versatile alternative media with widespread applications. DESs have the …

Enhanced binding of SARS-CoV-2 spike protein to receptor by distal polybasic cleavage sites

B Qiao, M Olvera de la Cruz - ACS nano, 2020 - ACS Publications
The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein plays a crucial role in
binding the human cell receptor ACE2 that is required for viral entry. Many studies have …

Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development

TJ Kamerzell, R Esfandiary, SB Joshi… - Advanced drug delivery …, 2011 - Elsevier
The purpose of this review is to demonstrate the critical importance of understanding protein–
excipient interactions as a key step in the rational design of formulations to stabilize and …

Antibody structure, instability, and formulation

W Wang, S Singh, DL Zeng, K King, S Nema - Journal of pharmaceutical …, 2007 - Elsevier
The number of therapeutic monoclonal antibody in development has increased
tremendously over the last several years and this trend continues. At present there are more …

Protein drug stability: a formulation challenge

S Frokjaer, DE Otzen - Nature reviews drug discovery, 2005 - nature.com
The increasing use of recombinantly expressed therapeutic proteins in the pharmaceutical
industry has highlighted issues such as their stability during long-term storage and means of …

Targeted gene knockout by direct delivery of zinc-finger nuclease proteins

T Gaj, J Guo, Y Kato, SJ Sirk, CF Barbas III - Nature methods, 2012 - nature.com
Zinc-finger nucleases (ZFNs) are versatile reagents that have redefined genome
engineering. Realizing the full potential of this technology requires the development of safe …

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

M Vedadi, FH Niesen… - Proceedings of the …, 2006 - National Acad Sciences
The 3D structures of human therapeutic targets are enabling for drug discovery. However,
their purification and crystallization remain rate determining. In individual cases, ligands …

Viscosity prediction of high-concentration antibody solutions with atomistic simulations

TM Prass, P Garidel, M Blech… - Journal of Chemical …, 2023 - ACS Publications
The computational prediction of the viscosity of dense protein solutions is highly desirable,
for example, in the early development phase of high-concentration biopharmaceutical …