Physiological‐based pharmacokinetic modeling trends in pharmaceutical drug development over the last 20‐years; in‐depth analysis of applications, organizations …
E El‐Khateeb, S Burkhill, S Murby… - … & Drug Disposition, 2021 - Wiley Online Library
We assess the advancement of physiologically based pharmacokinetic (PBPK) modeling
and simulation (M&S) over the last 20 years (start of 2000 to end of 2019) focusing on the …
and simulation (M&S) over the last 20 years (start of 2000 to end of 2019) focusing on the …
Toxicokinetics, dose–response, and risk assessment of nanomaterials: Methodology, challenges, and future perspectives
The rapid growth of nanomaterial applications has raised safety concerns for human health.
A number of studies have been conducted to assess the toxicokinetics, toxicology, dose …
A number of studies have been conducted to assess the toxicokinetics, toxicology, dose …
Meta-analysis of nanoparticle delivery to tumors using a physiologically based pharmacokinetic modeling and simulation approach
Numerous studies have engineered nanoparticles with different physicochemical properties
to enhance the delivery efficiency to solid tumors, yet the mean and median delivery …
to enhance the delivery efficiency to solid tumors, yet the mean and median delivery …
Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific …
Background Physiologically based pharmacokinetic (PBPK) modeling is an important tool in
predicting target organ dosimetry and risk assessment of nanoparticles (NPs). The …
predicting target organ dosimetry and risk assessment of nanoparticles (NPs). The …
Current approaches and techniques in physiologically based pharmacokinetic (PBPK) modelling of nanomaterials
There have been efforts to develop physiologically based pharmacokinetic (PBPK) models
for nanomaterials (NMs). Since NMs have quite different kinetic behaviors, the applicability …
for nanomaterials (NMs). Since NMs have quite different kinetic behaviors, the applicability …
Berkeley Madonna Version 10–A simulation package for solving mathematical models
FV Marcoline, J Furth, S Nayak… - CPT …, 2022 - Wiley Online Library
Berkeley Madonna is a software program that provides an easy and intuitive environment for
graphically building and numerically solving mathematical equations. Our users range from …
graphically building and numerically solving mathematical equations. Our users range from …
Physiologically based pharmacokinetic modeling of nanoparticle biodistribution: a review of existing models, simulation software, and data analysis tools
EO Kutumova, IR Akberdin, IN Kiselev… - International Journal of …, 2022 - mdpi.com
Cancer treatment and pharmaceutical development require targeted treatment and less toxic
therapeutic intervention to achieve real progress against this disease. In this scenario …
therapeutic intervention to achieve real progress against this disease. In this scenario …
Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment
Penicillin G is a widely used antimicrobial in food-producing animals, and one of the most
predominant drug residues in animal-derived food products. Due to reduced sensitivity of …
predominant drug residues in animal-derived food products. Due to reduced sensitivity of …
Physiologically based pharmacokinetic model validated to enable predictions of multiple drugs in a long-acting drug-combination nano-particles (DCNP): confirmation …
S Perazzolo, DD Shen, AM Scott, RJY Ho - Journal of Pharmaceutical …, 2024 - Elsevier
Abstract Drug-Combination Nanoparticles (DcNP) are a novel drug delivery system
designed for synchronized delivery of multiple drugs in a single, long-acting, and targeted …
designed for synchronized delivery of multiple drugs in a single, long-acting, and targeted …
A web-based interactive physiologically based pharmacokinetic (iPBPK) model for meloxicam in broiler chickens and laying hens
Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) commonly used in food-
producing animals, including chickens in an extralabel manner. This study aimed to develop …
producing animals, including chickens in an extralabel manner. This study aimed to develop …